Evaluation of muscle oxygenation by functional near-infrared spectroscopy in patients with myasthenia gravis during rest and exercise

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dc.authorid0000-0003-1028-6703
dc.authorid0000-0002-5955-5356
dc.authorid0000-0003-2098-0731
dc.authorid0000-0001-5928-8086
dc.authorid0000-0003-4292-5717
dc.contributor.authorCoşkun Semiz, Ebru
dc.contributor.authorAlökten, Merve
dc.contributor.authorKarakulak, Ece Zeynep
dc.contributor.authorAysal, Fikret
dc.contributor.authorHanoğlu, Lütfü
dc.date.accessioned2026-03-31T14:25:28Z
dc.date.available2026-03-31T14:25:28Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractIntroduction: Myasthenia gravis (MG) is an autoimmune disease that is caused by autoantibodies targeting the neuromuscular junction. A few studies in the literature show that MG may negatively affect muscle metabolism. However, no current study investigates MG pathophysiology’s effect on muscle oxygenation. In this study, we aimed to investigate the difference in muscle oxygenation in MG disease and to evaluate its clinical Pathophysiological implications. Methods: 19 MG patients and 19 age, gender and body mass index (BMI) matched healthy controls participated in the study. Functional near-infrared spectroscopy (fNIRS) recordings were recorded from six channels over the biceps brachii muscles during the rhythmic elbow flexion-extension task. Results: It was observed that oxygenated-hemoglobin (HbO) (p = 0.008) and total hemoglobin (HbT) (p = 0.017) values during exercise were significantly lower in MG patients in the motor point of the biceps brachii muscle. In addition, at rest, deoxygenated-hemoglobin (HbR) levels were significantly lower in patients (p<0.05) in the motor point and the lateral region of the biceps brachii muscles. Additionally, a difference is observed in fNIRS values between the moderate-severe MG group and healthy controls. Also, a negative correlation was observed between exercise-state HbO and rest-state HbR values and disease severity (p<0.05). Conclusion: MG patients show deterioration in muscle oxygenation values during exercise and rest. Oxygenation values show significant differences in disease severity and negatively correlate with disease severity. Based on these findings, MG disease may affect muscle oxygenation and can be monitored by fNIRS.
dc.identifier.citationCoşkun Semiz, E., Alökten, M., Karakulak, E. Z., Aysal, F., & Hanoğlu, L. (2026). Evaluation of muscle oxygenation by functional near-infrared spectroscopy in patients with myasthenia gravis during rest and exercise. Archives of Neuropsychiatry, 63, pp. 144-151. https://doi.org/10.29399/npa.28877
dc.identifier.doi10.29399/npa.28877
dc.identifier.endpage151
dc.identifier.issn1309-4866
dc.identifier.pmidPMID: 41777512
dc.identifier.scopus2-s2.0-105033264916
dc.identifier.scopusqualityQ3
dc.identifier.startpage144
dc.identifier.urihttps://doi.org/10.29399/npa.28877
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1372
dc.identifier.volume63
dc.identifier.wosWOS:001706037500002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorCoşkun Semiz, Ebru
dc.institutionauthorid0000-0003-1028-6703
dc.language.isoen
dc.publisherTurkish Neuropsychiatric Society
dc.relation.ispartofArchives of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFunctional Near-Infrared Spectroscopy (fNIRS)
dc.subjectMuscle Disease
dc.subjectMuscle Metabolism
dc.subjectMyasthenia Gravis
dc.subjectNeuromuscular Disease
dc.titleEvaluation of muscle oxygenation by functional near-infrared spectroscopy in patients with myasthenia gravis during rest and exercise
dc.typeArticle
dspace.entity.typePublication

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