A mixture of potent polyphenolic anticarcinogens: Microarray analysis of their efficacy in MCF-7 and MCF-10A cell lines

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dc.authorid0000-0002-6218-0049
dc.authorid0000-0002-8095-1759
dc.authorid0000-0003-2033-3577
dc.authorid0000-0001-8924-4850
dc.authorid0000-0002-3635-8421
dc.authorid0000-0002-8837-6664
dc.authorid0000-0001-6910-1131
dc.authorid0000-0002-2439-9269
dc.contributor.authorSeyhan, Mehmet Fatih
dc.contributor.authorEronat, Allison Pınar
dc.contributor.authorDiren, Ayça
dc.contributor.authorTüzüner, Mete Bora
dc.contributor.authorCeviz, Ayşe Begüm
dc.contributor.authorYılmaz Aydoğan, Hülya
dc.contributor.authorÖztürk, Tülin
dc.contributor.authorÖztürk, Oğuz
dc.date.accessioned2026-04-15T08:03:50Z
dc.date.available2026-04-15T08:03:50Z
dc.date.issued2026
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı
dc.description.abstractPolyphenols are abundantly available through diet and show great promise with their safe use against cancer. In our previous studies, we have shown cytotoxic effects of more than 30 polyphenols in breast cancer. In this study, we have aimed to investigate the effects of various polyphenols upon MCF-7 breast cancer and MCF-10A normal epithelial cells. To this end, we have designed a polyphenolic mixture based on the most effective concentrations of seven compounds, which is a first according to literature in terms of polyphenolic combi nation studies. Cell proliferation experiments were executed utilizing WST-1 and apoptotic status by Annexin V-PI. After determining most effective concentrations, we operated whole genome microarray analysis. Based on microarray data, the best effective concentration for both cell lines is 75% of polyphenolic mixture. In MCF-7 cell line, this dosage induced in down regulation of cell cycle, cell division, DNA repair and some genes linked to breast cancer. In contrast, no remarkable effect was observed in MCF-10A cell line. The designed polyphenolic mixture was demonstrated to inhibit breast cell division in multiple pathways. Our findings on cell division in MCF-7 cell line were found similarly with the study based on polyphenol rich propolis which inhibited cell division remarkably in SK-BR-3 cells. This mixture, which is shown to have highly effective anticarcinogenic effects, can be considered as a prototype of natural prescription design for our future research.
dc.description.sponsorshipThe present work was supported by the Research Fund of Istanbul University. Project No. 28301. Bu çalışma, İstanbul Üniversitesi Araştırma Fonu tarafından desteklenmiştir. Proje No. 28301.
dc.identifier.citationSeyhan, M. F., & Eronat, A. P., Diren, A., Tüzüner, M. B., Ceviz, A. B., Yılmaz Aydoğan, H., Öztürk, T., & Öztürk, O. (2026). A mixture of potent polyphenolic anticarcinogens: Microarray analysis of their efficacy in MCF-7 and MCF-10A cell lines. Records of Natural Products, 20(4), pp. 1-16. http://doi.org/10.25135/rnp.2510.3658
dc.identifier.doi10.25135/rnp.2510.3658
dc.identifier.endpage16
dc.identifier.issn1307-6167
dc.identifier.issue4
dc.identifier.scopus2-s2.0-105032800272
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttp://doi.org/10.25135/rnp.2510.3658
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1409
dc.identifier.volume20
dc.identifier.wosWOS:001709408700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorTüzüner, Mete Bora
dc.institutionauthorCeviz, Ayşe Begüm
dc.institutionauthorid0000-0001-8924-4850
dc.institutionauthorid0000-0002-3635-8421
dc.language.isoen
dc.publisherACG Publications
dc.relation.ispartofRecords of Natural Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPolyphenols
dc.subjectBreast Cancer
dc.subjectWhole Genome Expression
dc.subjectCell Proliferation
dc.subjectCell Division
dc.subjectMicroarray
dc.titleA mixture of potent polyphenolic anticarcinogens: Microarray analysis of their efficacy in MCF-7 and MCF-10A cell lines
dc.typeArticle
dspace.entity.typePublication

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