Diagnostic role of opsonic activity in Acinetobacter baumannii ventilator-associated pneumonia

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dc.authorid0000-0002-7117-5102en_US
dc.authorscopusid56246987300en_US
dc.authorwosidF-4464-2019en_US
dc.contributor.authorKarakullukçu, Asiye
dc.contributor.authorAkker, Mustafa
dc.contributor.authorKuşkucu, Mert Ahmet
dc.contributor.authorDikmen, Yalım
dc.contributor.authorAygün, Gökhan
dc.date.accessioned2024-04-15T06:49:16Z
dc.date.available2024-04-15T06:49:16Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractIn this study, we investigated the diagnostic value of opsonic activity against Acinetobacter baumannii in Ventilator-Associated Pneumonia (VAP) among 50 patients, compared to 102 negative and positive controls. Out of the 50 patients, only 33 (66 %) were diagnosed with VAP using the Clinical Pulmonary Infection Score (CPIS). The opsonic activity assay demonstrated three key findings: (i) 95 % sensitivity and 91.7 % specificity, with a Receiver Operating Characteristic (ROC) area of 0.976 for distinguishing A. baumannii culture positives from negatives; (ii) 95 % sensitivity and 78.7 % specificity, with a 0.915 ROC area, in differentiating VAP/blood culture positive patients from colonized/negative groups; (iii) An ROC area of 0.553 for VAP and colonization, as identified by CPIS alone, indicating an indeterminate threshold. These results highlight that CPIS, microbiological, and clinical evaluations were not correlated, suggesting that opsonic activity against A. baumannii could be a potential VAP diagnostic tool, with the need for large-scale validations.en_US
dc.description.sponsorshipIstanbul University Scientific Research Projects -- 40105en_US
dc.identifier.citationKarakullukçu, A., Akker, M., Kuşkucu, M. A., Dikmen, Y., & Aygün, G. (2024). Diagnostic role of opsonic activity in Acinetobacter baumannii ventilator-associated pneumonia. Diagnostic Microbiology & Infectious Disease, 109(3), pp. 1-6. https://doi.org/10.1016/j.diagmicrobio.2024.116262en_US
dc.identifier.doi10.1016/j.diagmicrobio.2024.116262en_US
dc.identifier.endpage6en_US
dc.identifier.issn0732-8893
dc.identifier.issn1879-0070
dc.identifier.issue3en_US
dc.identifier.pmidPMID: 38604074en_US
dc.identifier.scopus2-s2.0-85189972872en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.diagmicrobio.2024.116262
dc.identifier.urihttps://hdl.handle.net/20.500.13055/687
dc.identifier.volume109en_US
dc.identifier.wosWOS:001227835800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorKarakullukçu, Asiye
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofDiagnostic Microbiology & Infectious Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcinetobacter Baumanniien_US
dc.subjectVentilator-Associated Pneumonia (VAP)en_US
dc.subjectOpsonic Activityen_US
dc.subjectRapid Diagnostic Techniquesen_US
dc.subjectClinical Pulmonary İnfection Score (CPIS)en_US
dc.titleDiagnostic role of opsonic activity in Acinetobacter baumannii ventilator-associated pneumoniaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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