Photoinactivation of MRSA AТCC 33591 by antimicrobial photodynamic therapy using coumarin-functionalized zinc(II) phthalocyanine

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dc.authorid0000-0002-7734-8553
dc.authorid0000-0002-1311-6892
dc.authorid0009-0001-1448-2739
dc.authorid0000-0002-1575-5751
dc.authorid0000-0002-1192-6947
dc.authorid0000-0002-6424-7411
dc.contributor.authorBilgin, Merve
dc.contributor.authorElgün, Tuğba
dc.contributor.authorAktaş, Çiğdem
dc.contributor.authorKaragülle, Onur Olgaç
dc.contributor.authorÇınar, Kamil
dc.contributor.authorGök Yurttaş, Asiye
dc.date.accessioned2026-11-12T13:43:26Z
dc.date.available2026-11-12T13:43:26Z
dc.date.issued2026
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractThis study evaluates the photodynamic inactivation potential of a coumarin-functionalized zinc(II) phthalocyanine derivative against methicillin-resistant Staphylococcus aureus (MRSA) AТСC 33591. The antimicrobial and cytotoxic effects of the derivative were assessed under dark and laser-irradiated (658 nm) conditions. Minimum inhibitory concentration (MIC) values were determined, and the photodynamic response was further explored in MRSA-infected HT-29 (human colorectal adenocarcinoma) and HUVEC (human umbilical vein endothelial) cell models. While the derivative exhibited dose-dependent antibacterial activity, the light-induced reduction in colony-forming units (CFU) was moderate, remaining below a tenfold (1-log10) under the tested conditions. In cell-based assays, the compound showed detectable dark cytotoxicity,which was further enhanced upon laser irradiation. The photodynamic cytotoxic response was more pronounced in infected HT-29 cells than in infected HUVEC cells, with flow-cytometric profiles consistent with predominantly necrotic/late apoptotic cell-death patterns. These findings indicate that the compound exhibits light-enhanced effects in complex infection models; however, further optimization offormulation, photophysical properties, and light dosimetry is required to improve antimicrobial efficacy and selectivity.
dc.identifier.citationBilgin, M., Elgün, T., Aktaş, Ç., Karagülle, O. O., Çınar, K., & Gök Yurttaş, A. (2026). Photoinactivation of MRSA AТCC 33591 by antimicrobial photodynamic therapy using coumarin-functionalized zinc(II) phthalocyanine. Acta Chimica Slovenica, 73(3), pp. 515-521. https://doi.org/10.17344/acsi.2025.9638
dc.identifier.doi10.17344/acsi.2025.9638
dc.identifier.endpage521
dc.identifier.issn1318-0207
dc.identifier.issn1580-3155
dc.identifier.issue3
dc.identifier.pmidPMID: 42839567
dc.identifier.scopus2-s2.0-105051753821
dc.identifier.scopusqualityQ3
dc.identifier.startpage515
dc.identifier.urihttps://doi.org/10.17344/acsi.2025.9638
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1713
dc.identifier.volume73
dc.identifier.wosWOS:001888917800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorBilgin, Merve
dc.institutionauthorid0000-0002-7734-8553
dc.language.isoen
dc.publisherSlovensko Kemijsko Drustvo
dc.relation.ispartofActa Chimica Slovenica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMethicillin-Resistant Staphylococcus Aureus
dc.subjectMicrobial Pathogens
dc.subjectDose-Dependent Antibacterial Activity
dc.subjectPhotodynamic Inactivation
dc.subjectPhotosensitizing Phthalocyanine
dc.subjectLaser
dc.titlePhotoinactivation of MRSA AТCC 33591 by antimicrobial photodynamic therapy using coumarin-functionalized zinc(II) phthalocyanine
dc.typeArticle
dspace.entity.typePublication

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