Temporal trends and regional variations in hepatocellular carcinoma etiology: A multinational study across Asia

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dc.authorid0000-0003-3021-2517
dc.authorid0000-0003-3525-4708
dc.authorid0000-0003-2869-2881
dc.authorid0009-0009-4433-6001
dc.authorid0009-0009-9570-9007
dc.authorid0000-0002-1763-9439
dc.authorid0000-0002-6540-9064
dc.authorid0000-0002-8909-2102
dc.authorid0000-0002-0544-5610
dc.authorid0000-0001-7977-1497
dc.contributor.authorTakeuchi, Yasuto
dc.contributor.authorTateishi, Ryosuke
dc.contributor.authorObi, Shuntaro
dc.contributor.authorOtsuka, Motoyuki
dc.contributor.authorMochizuki, Hitoshi
dc.contributor.authorJazag, Amarsanaa
dc.contributor.authorYokosuka, Osamu
dc.contributor.authorOgasawara, Sadahisa
dc.contributor.authorÖrmeci, Necati
dc.contributor.authorSarin, Shiv Kumar
dc.contributor.authorOmata, Masao
dc.date.accessioned2026-02-07T11:15:50Z
dc.date.available2026-02-07T11:15:50Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground Hepatocellular carcinoma (HCC) remains a major health burden in Asia. Advances in antiviral therapies are reshaping the etiological landscape of HCC. This study evaluated temporal shifts in HCC etiology across Asian countries and their clinical implications. Methods This multinational study analyzed 6,261 newly diagnosed HCC patients registered in the APASL Hepatology/ Oncology Consortium (A-HOC) from 19 centers across seven Asian countries and regions between 2013 and 2023. Data on demographics, tumor characteristics, etiology, and treatment patterns were collected. Etiologies included hepatitis B virus (HBV), hepatitis C virus (HCV), alcoholic liver disease (ALD), metabolic dysfunction-associated fatty liver disease (MAFLD), MAFLD plus excess alcoholic intake (MAFLD +eAL), autoimmune liver disease, cryptogenic, and others. Temporal trends and regional variations were assessed. Results In many countries, HBV remained predominant (43.3%–69.5%) and relatively stable throughout the period, while HCV showed only modest reductions. In Japan, HCV was the leading cause of HCC (33.1%), with a significant decline over time, accompanied by a rise in MAFLD-related HCC. ALD-related HCC increased in South Korea, and MAFLD-related HCC rose in Turkey. Tumor size and stage at diagnosis varied by etiology and region, affecting treatment strategies. Early stage diagnosis was more frequent in Japan and Taiwan, whereas advanced-stage HCC was common in China and Indonesia. Conclusions Distinct regional patterns and temporal changes in HCC etiology across Asia highlight the need for tailored prevention and surveillance measures. The growing burden of MAFLD-related HCC emphasizes its emerging role in liver cancer development, particularly in regions with declining viral hepatitis.
dc.description.sponsorshipOpen Access funding provided by The University of Tokyo. This study was supported by the APASL (Grant number: [AHOC20230501]). Açık Erişim fonlaması Tokyo Üniversitesi tarafından sağlanmıştır. Bu çalışma APASL tarafından desteklenmiştir (Burs numarası: [AHOC20230501]).
dc.identifier.citationTakeuchi, Y., Tateishi, R., Obi, S., Otsuka, M., Mochizuki, H., Jazag, A., Yokosuka, O., Ogasawara, S., Örmeci, N., Sarin, S. K., & Omata, M. (2026). Temporal trends and regional variations in hepatocellular carcinoma etiology: A multinational study across Asia. Hepatology International, https://doi.org/10.1007/s12072-026-11037-z
dc.identifier.doi10.1007/s12072-026-11037-z
dc.identifier.issn1936-0541
dc.identifier.issn1936-0533
dc.identifier.pmidPMID: 41639358
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s12072-026-11037-z
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1293
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorÖrmeci, Necati
dc.institutionauthorid0000-0002-8909-2102
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofHepatology International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHepatocellular Carcinoma
dc.subjectEpidemiology
dc.subjectTemporal Trend
dc.subjectAsia
dc.titleTemporal trends and regional variations in hepatocellular carcinoma etiology: A multinational study across Asia
dc.typeArticle
dspace.entity.typePublication

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