Comprehensive analyses of sox7 provide novel insights on its tumor suppressor role and its target genes with therapeutic implications in multiple myeloma

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dc.authorid0000-0001-9331-6749
dc.authorid0000-0003-0115-9884
dc.authorid0000-0002-0930-6300
dc.authorid0000-0001-7931-7104
dc.authorid0000-0002-7092-4845
dc.authorid0000-0001-5540-9012
dc.contributor.authorCeylan, Arda
dc.contributor.authorHu, Xiaozhou
dc.contributor.authorHatipoğlu, Tevfik
dc.contributor.authorNainkwi, Fenangi Chiara
dc.contributor.authorPayzın, Kadriye Bahriye
dc.contributor.authorÖzsan, Güner Hayri
dc.contributor.authorŞirinoğlu Demiriz, Itır
dc.contributor.authorŞeker, Ömer
dc.contributor.authorKakçı, Merve
dc.contributor.authorKüçük, Can
dc.date.accessioned2026-10-22T17:37:49Z
dc.date.available2026-10-22T17:37:49Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractMultiple myeloma (MM) is an incurable hematological malignancy. SOX7, located within the recurrently deleted 8p23.1 region in MM, is suggested to act as a tumor suppressor. We characterized SOX7 through genetic, epigenetic, and functional analyses in MM cell lines. SOX7 was frequently silenced due to deletion and/or promoter hypermethylation. Ectopic SOX7 expression in KMS-18 and MM.1S cell lines caused a progressive decline in SOX7-transduced cells and induced G1 cell cycle arrest and/or apoptosis. Although SOX7 re-expression did not enhance bortezomib efficacy, treatment with the pan-histone deacetylase inhibitor panobinostat induced G1 arrest, promoted apoptosis, and increased SOX7 expression in MM.1S cells. Whole-transcriptome sequencing identified G1/S progression-related Wnt/β-catenin pathway genes as major SOX7-regulated targets, while ChIP-Seq analysis revealed widespread genomic SOX7 occupancy in MM.1S. Flow cytometric analysis of permeabilized bone marrow tumor cells from newly diagnosed and relapsed MM patients demonstrated generally low SOX7 protein expression. Collectively, these results indicate that SOX7 functions as a tumor suppressor in MM, and its inactivation promotes cell cycle progression. The anti-myeloma effects of panobinostat in MM.1S cells may be partially mediated through SOX7 induction.
dc.description.sponsorshipThis study was supported by TÜB˙ ITAK (The Scientific and Technological Research Council of Türkiye) 1001 program (no: 120S945) (C.K.). Bu çalışma, TÜBİTAK (Türkiye Bilimsel ve Teknolojik Araştırma Kurumu) 1001 programı (no: 120S945) tarafından desteklenmiştir (C.K.).
dc.identifier.citationCeylan, A., Hu, X., Hatipoğlu, T., Nainkwi, F. C., Payzın, K. B., Özsan, G. H., Şirinoğlu Demiriz, I., Şeker, Ö., Kakçı, M., & Küçük, C. (2026). Comprehensive analyses of sox7 provide novel insights on its tumor suppressor role and its target genes with therapeutic implications in multiple myeloma. International Journal of Molecular Sciences, 27(17), pp. 1-24. https://doi.org/10.3390/ijms27177648
dc.identifier.doi10.3390/ijms27177648
dc.identifier.endpage24
dc.identifier.issn1422-0067
dc.identifier.issue17
dc.identifier.pmidPMID: 42737548
dc.identifier.scopus2-s2.0-105050349359
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/ijms27177648
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1679
dc.identifier.volume27
dc.identifier.wosWOS:001873013700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorŞirinoğlu Demiriz, Itır
dc.language.isoen
dc.publisherMDPI Publishing
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSOX7
dc.subjectMultiple Myeloma
dc.subjectTumor Suppressor Gene
dc.subjectWhole-Transcriptome Sequencing
dc.subjectChIP-Seq
dc.subjectWnt/Β-Catenin Pathway
dc.subjectPanobinostat
dc.titleComprehensive analyses of sox7 provide novel insights on its tumor suppressor role and its target genes with therapeutic implications in multiple myeloma
dc.typeArticle
dspace.entity.typePublication

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