Clinically relevant depression in patients with type 1 and type 2 diabetes; A nationwide study (TEMD-2 depression)

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dc.authorid0000-0002-8023-2666
dc.authorid0000-0003-0498-3115
dc.authorid0000-0002-6866-2364
dc.authorid0000-0003-3819-5061
dc.authorid0000-0001-7490-2937
dc.authorid0000-0001-9259-7024
dc.authorid0000-0003-3442-420X
dc.authorid0000-0003-3122-5491
dc.authorid0000-0003-4867-3725
dc.authorid0000-0002-9309-7715
dc.contributor.authorYüksel Güler, Bağdagül
dc.contributor.authorDemirci, İbrahim
dc.contributor.authorHaymana, Cem
dc.contributor.authorAkbay, Esen
dc.contributor.authorEvren, Bahri
dc.contributor.authorDizdar, Oğuzhan Sıtkı
dc.contributor.authorDemir, Orhan
dc.contributor.authorAğbaht, Kemal
dc.contributor.authorSalman, Serpil
dc.contributor.authorSönmez, Alper
dc.date.accessioned2026-10-13T13:50:00Z
dc.date.available2026-10-13T13:50:00Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose Depression is a common but underrecognized comorbidity in individuals with diabetes and is associated with adverse clinical outcomes. This nationwide study aimed to determine the prevalence of clinically relevant depression (CRD) among adults with type 1 and type 2 diabetes in Türkiye and to identify clinical and metabolic factors independently associ ated with CRD. Methods This cross-sectional analysis was conducted within the Turkish nationwide survEy of glycemic and other Meta bolic parameters of patients with Diabetes mellitus-2 (TEMD-2), a multicenter study including adults followed in tertiary endocrinology centers across Türkiye. CRD was defined as a Patient Health Questionnaire-9 score ≥ 10 and/or current anti depressant use. Results A total of 5.266 patients were included. The prevalence of CRD was similar in type 1 and type 2 diabetes (29.4% vs. 27.6%, p = 0.345). In both diabetes types, CRD was significantly more common among women. Patients with CRD had higher body mass index, poorer glycemic control, higher rates of hypoglycemia, and lower achievement of metabolic targets. Microvascular and macrovascular complications were more frequent in patients with CRD. In multivariable analyses, female sex, smoking, and polypharmacy were independently associated with CRD in both diabetes types, while obesity, poor glyce mic control, and vascular complications were additional independent associates in type 2 diabetes. Conclusion CRD affects nearly one-third of adults with diabetes, regardless of diabetes type, and is associated with greater comorbidity burden and suboptimal metabolic control. These findings support routine depression screening as an integral component of comprehensive diabetes care. The study is registered at ClinicalTrials.gov (NCT06347445).
dc.description.sponsorshipThis study was supported by the Turkish Society of Endocri nology and Metabolism (TEMD). Bu çalışma Türk Endokrinoloji ve Metabolizma Derneği (TEMD) tarafından desteklenmiştir.
dc.identifier.citationYüksel Güler, B., Demirci, İ., Haymana, C., Akbay, E., Evren, B., Dizdar, O. S., Demir, O., Ağbaht, K., Salman, S., & Sönmez, A. (2026). Clinically relevant depression in patients with type 1 and type 2 diabetes; A nationwide study (TEMD-2 depression). Endocrine, 91(1), pp. 1-15. https://doi.org/10.1007/s12020-026-04676-7
dc.identifier.doi10.1007/s12020-026-04676-7
dc.identifier.endpage15
dc.identifier.issn1559-0100
dc.identifier.issn1355-008XE
dc.identifier.issue1
dc.identifier.pmidPMID: 42714690
dc.identifier.scopus2-s2.0-105050144533
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1007/s12020-026-04676-7
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1669
dc.identifier.volume91
dc.identifier.wosWOS:001871767600005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorSalman, Serpil
dc.institutionauthorid0000-0003-4867-3725
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofEndocrine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectClinically Relevant Depression
dc.subjectType 1 Diabetes
dc.subjectType 2 Diabetes
dc.subjectMetabolic Control
dc.subjectDepression Screening
dc.titleClinically relevant depression in patients with type 1 and type 2 diabetes; A nationwide study (TEMD-2 depression)
dc.typeArticle
dspace.entity.typePublication

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