Inactivation of Nosema spp. with zinc phthalacyonine

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dc.authorid0000-0002-6424-7411en_US
dc.authorscopusid57366670900en_US
dc.authorwosidCJT-9277-2022en_US
dc.contributor.authorGök Yurttaş, Asiye
dc.contributor.authorÇınar, Kamil
dc.contributor.authorKhan, Zaeema
dc.contributor.authorElgün, Tuğba
dc.contributor.authorMayack, Christopher
dc.date.accessioned2024-02-19T06:07:38Z
dc.date.available2024-02-19T06:07:38Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalıen_US
dc.description.abstractMost honey bee pathogens, such as Vairimorpha (Nosema), cannot be rapidly and definitively diagnosed in a natural setting, consequently there is typically the spread of these diseases through shared and re-use of beekeeping equipment. Furthermore, there are no viable treatment options available for Nosema spores to aid in managing the spread of this bee disease. We therefore aimed to develop a new method using novel Zinc Phthalacyonine (ZnPc) as a photosensitizer for the photodynamic inactivation of Nosema spores that could be used for the decontamination of beekeeping equipment. Nosema spores were propagated for in vitro testing using four caged Apis mellifera honey bees. The ZnPc treatment was characterized, encapsulated with a liposome, and then used as either a 10 or 100 µM treatment for the freshly harvested Nosema spores, for either a 30 and or 60-minute time period, under either light or dark conditions, in-vitro, in 96-well plates. In the dark treatment, after 30-min, the ZnPc 100 µM treatment, caused a 30 % Nosema mortality, while this increased to 80 % at the same concentration after the light treatment. The high rate of anti-spore effects, in a short period of time, supports the notion that this could be an effective treatment for managing honey bee Nosema infections in the future. Our results also suggest that the photo activation of the treatment could be applied in the field setting and this would increase the sterilization of beekeeping equipment against Nosema.en_US
dc.identifier.citationGök Yurttaş, A., Çınar, K., Khan, Z., Elgün, T., & Mayack, C. (2024). Inactivation of Nosema spp. with zinc phthalacyonine. Journal of Invertebrate Pathology, 203, pp. 1-8 https://doi.org/10.1016/j.jip.2024.108074en_US
dc.identifier.doi10.1016/j.jip.2024.108074en_US
dc.identifier.endpage8en_US
dc.identifier.issn1096-0805
dc.identifier.issn0022-2011
dc.identifier.pmidPMID: 38350524en_US
dc.identifier.scopus2-s2.0-85185582797en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jip.2024.108074
dc.identifier.urihttps://hdl.handle.net/20.500.13055/653
dc.identifier.volume203en_US
dc.identifier.wosWOS:001199481600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorGök Yurttaş, Asiye
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Invertebrate Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/121O785
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBee Healthen_US
dc.subjectHoney Beeen_US
dc.subjectNosema Sporesen_US
dc.subjectPhthalocyanineen_US
dc.subjectPhotoinactivationen_US
dc.titleInactivation of Nosema spp. with zinc phthalacyonineen_US
dc.typeArticleen_US
dspace.entity.typePublication

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