The understanding of the importance of oxidant/antioxidant status in hemophilia patients with arthropathy

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dc.authorid0000-0002-6432-3541
dc.authorid0000-0002-0978-7992
dc.authorid0000-0003-1086-2184
dc.authorid0000-0002-2913-0728
dc.authorid0000-0002-8484-5822
dc.authorid0000-0002-2577-9263
dc.authorid0000-0002-7586-6939
dc.contributor.authorBingül, İlknur
dc.contributor.authorKoç Şenol, Başak
dc.contributor.authorHanikoğlu, Ayşegül
dc.contributor.authorDelen, Elif
dc.contributor.authorÖmer, Beyhan
dc.contributor.authorGenç, Nilgün Sema
dc.contributor.authorZülfikar, Bülent
dc.date.accessioned2025-11-06T08:03:02Z
dc.date.available2025-11-06T08:03:02Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractThis study aimed to investigate the roles of pro-inflammatory cytokine [interleukin-1β (IL-1β)], receptor activator of nuclear factor-kappa B ligand (RANKL), prooxidant [reactive oxygen species (ROS), thiobarbituric acid reactive sub stances (TBARS), advanced oxidation protein products (AOPP), advanced glycation end-products (AGEs)], and antioxi dant markers [ferric reducing antioxidant power (FRAP), total-thiol content (t-SH)] in the pathogenesis of arthropathy in patients with hemophilia (PwH) with/without arthropathy, and to identify potential therapeutic targets for preventing arthropathy and improving quality of life. The study included 18 PwH without arthropathy [31.0 years; (13–65)] and 39 PwH with arthropathy [10 years; (3–36)]. Among PwH with arthropathy, 6% were inhibitor positive, and 26.3% had involvement of more than two joints. Serum ROS and AGE were measured by fluorometric method, while TBARS, AOPP, FRAP, and t-SH were assessed via spectrophotometrically. IL-1β and RANKL concentrations were determined using ELISA. AGE and RANKL concentrations were significantly higher in PwH with arthropathy compared to those without (p=0.002 and p=0.010, respectively), and differences remained significant after age adjustment. FRAP and t-SH levels were initially elevated in PwH with arthropathy (p=0.030 and p=0.007, respectively), but differences lost significance after age adjustment. No significant differences were observed in ROS, TBARS, AOPP, or IL-1β levels between groups. Elevated AGE and RANKL levels in PwH with arthropathy suggest their potential involvement in joint damage and highlight the importance of maintaining oxidant/antioxidant balance. Therefore, monitoring these biomarkers may provide supportive information for early detection and inform future research on preventive strategies to reduce joint complications and preserve long-term quality of life in hemophilia.
dc.identifier.citationBingül, İ., Koç Şenol, B., Hanikoğlu, A., Delen, E., Ömer, B., Genç, N. S., & Zülfikar, B. (2025). The understanding of the importance of oxidant/antioxidant status in hemophilia patients with arthropathy. Indian Journal of Hematology and Blood Transfusion, https://doi.org/10.1007/s12288-025-02211-8
dc.identifier.doi10.1007/s12288-025-02211-8
dc.identifier.issn0974-0449
dc.identifier.issn0971-4502
dc.identifier.scopus2-s2.0-105021011851
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1007/s12288-025-02211-8
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1164
dc.identifier.wosWOS:001607954500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorHanikoğlu, Ayşegül
dc.institutionauthorDelen, Elif
dc.institutionauthorÖmer, Beyhan
dc.institutionauthorGenç, Nilgun Sema
dc.institutionauthorid0000-0003-1086-2184
dc.institutionauthorid0000-0002-2913-0728
dc.institutionauthorid0000-0002-8484-5822
dc.institutionauthorid0000-0002-2577-9263
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofIndian Journal of Hematology and Blood Transfusion
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHemophilia A
dc.subjectHemophilic Arthropathy
dc.subjectPro-Oxidant/Antioxidant Balance
dc.subjectReactive Oxygen Species
dc.titleThe understanding of the importance of oxidant/antioxidant status in hemophilia patients with arthropathy
dc.typeArticle
dspace.entity.typePublication

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