ROI-based analysis of diffusion indices in healthy subjects and subjects with deficit or non-deficit syndrome schizophrenia

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dc.authorid0000-0001-6728-3664en_US
dc.authorscopusid53867313500en_US
dc.authorwosidN-5682-2018en_US
dc.contributor.authorTürk, Yaşar
dc.contributor.authorDevecioğlu, İsmail
dc.contributor.authorKüskün, Atakan
dc.contributor.authorÖge, Cem
dc.contributor.authorBeyazyüz, Elmas
dc.contributor.authorAlbayrak, Yakup
dc.date.accessioned2023-11-14T11:15:54Z
dc.date.available2023-11-14T11:15:54Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalıen_US
dc.description.abstractWe analyzed DTI data involving 22 healthy subjects (HC), 15 patients with deficit syndrome schizophrenia (DSZ), and 25 patients with non-deficit syndrome schizophrenia (NDSZ). We used a 1.5-T MRI scanner to collect diffusion-weighted images and T1 images, which were employed to correct distortions and deformations within the diffusion-weighted images. For 156 regions of interest (ROI), we calculated the average fractional anisotropy (FA), mean diffusion (MD), and radial diffusion (RD). Each ROI underwent a group-wise comparison using permutation F-test, followed by post hoc pairwise comparisons with Bonferroni correction. In general, we observed lower FA in both schizophrenia groups compared to HC (i.e., HC>(DSZ=NDSZ)), while MD and RD showed the opposite pattern. Notably, specific ROIs with reduced FA in schizophrenia patients included bilateral nucleus accumbens, left fusiform area, brain stem, anterior corpus callosum, left rostral and caudal anterior cingulate, right posterior cingulate, left thalamus, left hippocampus, left inferior temporal cortex, right superior temporal cortex, left pars triangularis and right lingual gyrus. Significantly, the right cuneus exhibited lower FA in the DSZ group compared to other groups ((HC=NDSZ)>DSZ), without affecting MD and RD. These results indicate that compromised neural integrity in the cuneus may contribute to the pathophysiological distinctions between DSZ and NDSZ.en_US
dc.description.sponsorshipTekirdağ Namık Kemal University -- NKUBAP.02.GA.18.17en_US
dc.identifier.citationTürk, Y., Devecioğlu, İ., Küskün, A., Öge, C., Beyazyüz, E., & Albayrak, Y. (2023). ROI-based analysis of diffusion indices in healthy subjects and subjects with deficit or non-deficit syndrome schizophrenia. Psychiatry Research: Neuroimaging, 336, pp. 1-9. https://doi.org/10.1016/j.pscychresns.2023.111726en_US
dc.identifier.doi10.1016/j.pscychresns.2023.111726en_US
dc.identifier.endpage9en_US
dc.identifier.issn0925-4927
dc.identifier.issn1872-7506
dc.identifier.pmidPMID: 37925764en_US
dc.identifier.scopus2-s2.0-85175611235en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.pscychresns.2023.111726
dc.identifier.urihttps://hdl.handle.net/20.500.13055/583
dc.identifier.volume336en_US
dc.identifier.wosWOS:001110981700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorTürk, Yaşar
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPsychiatry Research: Neuroimagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDeficit Syndrome Schizophreniaen_US
dc.subjectDiffusion Tensor Imagingen_US
dc.subjectDiffusivityen_US
dc.subjectFractional Anisotropyen_US
dc.subjectNondeficit Syndrome Schizophreniaen_US
dc.subjectROI-Based Analysisen_US
dc.subjectSchizophreniaen_US
dc.titleROI-based analysis of diffusion indices in healthy subjects and subjects with deficit or non-deficit syndrome schizophreniaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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