A little-known vaginitis-like picture: Cytolytic vaginosis

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dc.authorid0000-0002-6726-0048
dc.authorid0000-0002-5812-4861
dc.contributor.authorKömeç, Selda
dc.contributor.authorAydın, Mustafa Derya
dc.date.accessioned2025-02-07T14:01:05Z
dc.date.available2025-02-07T14:01:05Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractBackground: Cytolytic vaginosis (CV) is a condition characterized by an increase in lactobacilli in the vaginal flora, causing complaints of discharge, itching, dyspareunia, and dysuria. Since there are no antimicrobials in the treatment protocols of CV, the diagnostic and therapeutic criteria of which were first defined by Cibley, differential diagnosis of CV from other vaginitis agents will prevent unnecessary use of antimicrobials and recurrent com-plaints. In our study, we aimed to determine the frequency of CV in patients presenting with vaginitis complaints and the diagnostic accuracy of the diagnostic criteria. Methods: In total, 140 women, 103 with vaginitis complaints and 37 without vaginitis complaints, were examined for bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), Trichomonas vaginalis (Tv), and CV. For the diagnosis of CV, vaginal pH ≤ 4.5, the presence of a large number of lactobacilli in Gram staining, the presence of false clue cells, cytolysis in vaginal epithelial cells, leukocyte deficiency or absence, absence of Tv, BV, or VVC were used. Results: Out of 103 patients, 30 (29.1%) had BV, 20 (19.4%) had VVC, 20 (19.4%) had CV, 5 (4.9%) had BV and VVC, and 4 (3.9%) had Tv. The sensitivity and specificity of the diagnostic criteria were 80% and 99% for epithelial cytolysis, 70% and 99% for false clue cells, 100% and 86% for pH ≤ 4.5, and 100% and 56% for numerous lactobacilli, respectively. Conclusions: In Turkey and worldwide, CV is not considered in vaginitis cases. In our study, the high rate of 19.4% in vaginitis cases shows the need for comprehensive research on this subject.
dc.identifier.citationKömeç, S., & Aydın, M. D. (2025). A little-known vaginitis-like picture: Cytolytic vaginosis. Clinical Laboratory, 71(1), https://doi.org/10.7754/Clin.Lab.2024.240709
dc.identifier.doi10.7754/Clin.Lab.2024.240709
dc.identifier.issn1433-6510
dc.identifier.issue1
dc.identifier.pmid39808145
dc.identifier.scopus2-s2.0-85215116282
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2024.240709
dc.identifier.urihttps://hdl.handle.net/20.500.13055/913
dc.identifier.volume71
dc.identifier.wosqualityQ4
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorAydın, Mustafa Derya
dc.institutionauthorid0000-0002-5812-4861
dc.language.isoen
dc.publisherClinical Laboratory Publications
dc.relation.ispartofClinical Laboratory
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCytolytic Vaginosis
dc.subjectFalse Clue Cell
dc.subjectLactobacilli
dc.subjectVaginitis
dc.titleA little-known vaginitis-like picture: Cytolytic vaginosis
dc.typeArticle
dspace.entity.typePublication

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