Cytotoxic and anti-migratory effects of polyphenolic compounds on breast cancer cells by altering Jam-A, LFA-1, and VLA-4 gene expression

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dc.authorid0000-0002-4383-6890
dc.authorid0000-0002-3635-8421
dc.authorid0000-0002-8095-1759
dc.authorid0000-0003-3906-977X
dc.authorid0000-0002-2439-9269
dc.authorid0000-0002-8837-6664
dc.contributor.authorÖzkara, Gülçin
dc.contributor.authorCeviz, Ayşe Begüm
dc.contributor.authorEronat, Allison Pinar
dc.contributor.authorPehlevan Karabıyık, Funda
dc.contributor.authorCandan, Gonca
dc.contributor.authorÖzturk, Oğuz
dc.contributor.authorYılmaz Aydoğan, Hülya
dc.date.accessioned2025-05-07T11:36:20Z
dc.date.available2025-05-07T11:36:20Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı
dc.description.abstractThis study represents the initial research of the effects of a com bination of the largest number (13) of different polyphenic sub stances (PFK5120), formulated based on the propolis content on cell viability, migration and expression of lymphocyte function-associated antigen-1 (LFA-1), very late antigen-4 (VLA-4) and junction adhesion molecule A (Jam-A) in breast cancer (BC) cells. PFK5120 negatively affected cell viability at a 5% concentra tion as compared with unexposed ones (p<0.001). Treatment with 20% PFK5120 for 48h down-regulated Jam-A in MCF-7 and MCF-10A, up-regulated LFA-1 in MCF-10A and MDA-MB-231, and down-regulated VLA-4 in MCF-10A and MDA-MB-231 (p<0.001). Furthermore, migration was found to be inhibited by PFK5120 at varying doses and times. Migration was completely inhibited by 35% PFK5120 treatment in MDA-MB-231, while even lower concen trations (10%) were effective in MCF-7. Current findings indicate that PFK5120 represents a valuable natural component of BC ther apy through its cytotoxic and anti-migratory effects.
dc.description.sponsorshipThe study was supported by the Istanbul University Research Fund (project number 27649).
dc.identifier.citationÖzkara, G., Ceviz, A. B., Eronat, A. P., Pehlevan Karabıyık, F., Candan, G., Özturk, O., & Yılmaz Aydoğan, H. (2025). Cytotoxic and anti-migratory effects of polyphenolic compounds on breast cancer cells by altering Jam-A, LFA-1, and VLA-4 gene expression. Natural Product Research, pp. 1-12. https://doi.org/10.1080/14786419.2025.2494629
dc.identifier.doi10.1080/14786419.2025.2494629
dc.identifier.endpage12
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1080/14786419.2025.2494629
dc.identifier.urihttps://hdl.handle.net/20.500.13055/977
dc.identifier.wosqualityQ3
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorCeviz, Ayşe Begüm
dc.institutionauthorid0000-0002-3635-8421
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofNatural Product Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPolyphenols
dc.subjectBreast Cancer
dc.subjectCell Migration
dc.subjectJam-A
dc.subjectLFA-1
dc.subjectVLA-4
dc.titleCytotoxic and anti-migratory effects of polyphenolic compounds on breast cancer cells by altering Jam-A, LFA-1, and VLA-4 gene expression
dc.typeArticle
dspace.entity.typePublication

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