Predicting risk of lymph node metastasis in papillary thyroid cancer using miRNAs and clinicopathological features

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dc.authorid0009-0003-5904-1368
dc.authorid0000-0001-7520-070X
dc.authorid0000-0002-3635-8421
dc.authorid0000-0001-9652-4332
dc.authorid0000-0001-6577-8970
dc.authorid0000-0002-8837-6664
dc.authorid0000-0002-2439-9269
dc.authorid0000-0001-6910-1131
dc.contributor.authorErgün, Penbe Gül
dc.contributor.authorAydoğan, Çağatay
dc.contributor.authorCeviz, Ayşe Begüm
dc.contributor.authorCandan, Gonca
dc.contributor.authorBatur, Şebnem
dc.contributor.authorYılmaz Aydoğan, Hülya
dc.contributor.authorÖztürk, Oğuz
dc.contributor.authorÖztürk, Tülin
dc.date.accessioned2025-06-25T10:43:04Z
dc.date.available2025-06-25T10:43:04Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı
dc.description.abstractThis study investigates potential prognostic values in models created with clinico pathological features and expression profles of miRNAs known for their critical roles in papillary thyroid carcinoma (PTC) for lymph node metastasis (LNM) in PTC cases. Forty-seven lymph node-metastatic PTC patients and 46 non-metastatic patients were included. Using RT-PCR, miR-21, miR-146b, miR-221, and miR-222 expression was analyzed in carcinoma tissues and metastatic lymph nodes of the same PTC patients and carcinoma tissues of non-metastatic PTC patients. MiR 146b (p<0.001) and miR-221 (p=0.009) were overexpressed in metastatic PTCs compared to non-metastatic PTCs. The miRNA expression profles were similar in the lymph nodes and primary cancer of metastatic PTCs. In the presence of larger tumors (>1 cm) in metastatic PTCs, miR-146b and miR221 were overexpressed in the tumor tissue (p=0.036), while miR-222 was overexpressed in metastatic lymph nodes (p=0.035). miR-146b was also upregulated in lack of peritumoral lympho cyte infltration (p=0.006). In conclusion, our fndings suggest that the overexpres sion of miR-146b and miR-221 in PTC tissues may be associated with lymph node metastasis and a poorer prognosis. Furthermore, the presence of larger tumors and increased levels of intratumoral fbrosis in non-metastatic PTC patients could indi cate a poor prognosis.
dc.description.sponsorshipThis work was supported by the Scientifc Projects Coordination Unit, Istanbul University-Cer rahpasa under Grant TTU-2019-3360 Bu çalışma, İstanbul Üniversitesi-Cerrahpaşa Bilimsel Projeler Koordinasyon Birimi tarafından TTU-2019-3360 numaralı hibe ile desteklenmiştir.
dc.identifier.citationErgün, P. G., Aydoğan, Ç., Ceviz, A. B., Candan, G., Batur, Ş., Yılmaz Aydoğan, H., Öztürk, O., & Öztürk, T. (2025). Predicting risk of lymph node metastasis in papillary thyroid cancer using miRNAs and clinicopathological features. Biochemical Genetics, https://doi.org/10.1007/s10528-025-11168-2
dc.identifier.doi10.1007/s10528-025-11168-2
dc.identifier.issn1573-4927
dc.identifier.pmidPMID: 40528062
dc.identifier.scopus2-s2.0-105008354938
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s10528-025-11168-2
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorCeviz, Ayşe Begüm
dc.institutionauthorid0000-0002-3635-8421
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofBiochemical Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectThyroid
dc.subjectPapillary Carcinoma
dc.subjectLymph Node Metastasis
dc.subjectMi-RNA
dc.subjectPrognosis
dc.titlePredicting risk of lymph node metastasis in papillary thyroid cancer using miRNAs and clinicopathological features
dc.typeArticle
dspace.entity.typePublication

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