Evaluation of posterior segment changes in pediatric asthma patients with and without inhaled corticosteroid therapy

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dc.authorid0000-0003-1694-6864
dc.authorid0000-0001-7348-7081
dc.authorid0000-0002-6055-7746
dc.authorid0000-0001-6831-3407
dc.authorid0000-0002-1720-9711
dc.contributor.authorKıvrak, Ulviye
dc.contributor.authorÇiçek, Fatih
dc.contributor.authorKöle, Mehmet Tolga
dc.contributor.authorKaya Adaş, Büşra
dc.contributor.authorKandemir, İbrahim
dc.date.accessioned2025-08-16T16:17:29Z
dc.date.available2025-08-16T16:17:29Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractThis study aimed to evaluate and compare changes in the posterior segment of pediatric asthma patients, potentially associated with asthma or inhaled corticosteroids. A retrospective analysis was conducted on children aged 7–17 diagnosed with atopic asthma. The participants were categorized into groups: Group 1 (no inhaled corticosteroids) and Group 2 (inhaled corticosteroid treatment). A control group of healthy children was also included. Demographic data, clinical findings, and laboratory results (e.g., eosinophil count, IgE, CRP levels) were collected. Optical coherence tomography (OCT) and OCT angiography (OCTA) were used to measure posterior segment parameters. Asthma patients demonstrated a statistically significant reduction in subfoveal choroidal thickness, the superficial capillary plexus in the superior and nasal quadrants, the choriocapillaris in the foveal quadrant, and the peripapillary vascular density in the inferior and superior quadrants compared to controls. Inflammation markers such as eosinophil count and CRP showed significant correlations with changes in vascular density. Asthma, as a chronic inflammatory and hypoxic condition, can significantly affect posterior segment parameters, leading to potential visual function impairments in children. Regular monitoring with OCT and OCTA can help detect early microvascular changes, allowing for timely interventions to preserve visual health.
dc.identifier.citationKıvrak, U., Çiçek, F., Köle, M. T., Kaya Adaş, B., & Kandemir, İ. (2025). Evaluation of posterior segment changes in pediatric asthma patients with and without inhaled corticosteroid therapy. Scientific Reports, 15, pp. 1-8. https://doi.org/10.1038/s41598-025-14024-w
dc.identifier.doi10.1038/s41598-025-14024-w
dc.identifier.endpage8
dc.identifier.issn2045-2322
dc.identifier.pmidPMID: 40770020
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1038/s41598-025-14024-w
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1075
dc.identifier.volume15
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorKandemir, İbrahim
dc.institutionauthorid0000-0002-1720-9711
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAsthma
dc.subjectInhaled Corticosteroid
dc.subjectOptic Coherence Tomography Angiography
dc.subjectVascular Density
dc.titleEvaluation of posterior segment changes in pediatric asthma patients with and without inhaled corticosteroid therapy
dc.typeArticle
dspace.entity.typePublication

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