Antibiotic adjuvant activities of quorum sensing signal molecules DSF and BDSF against mature biofilms of Staphylococci

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dc.authorid0000-0002-7734-8553en_US
dc.authorscopusid57528712600en_US
dc.authorwosidGYA-8234-2022en_US
dc.contributor.authorBilgin, Merve
dc.contributor.authorDöşler, Sibel
dc.contributor.authorÖtük, Gülten
dc.date.accessioned2023-10-31T06:21:13Z
dc.date.available2023-10-31T06:21:13Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractAmong promising antibiofilm compounds, quorum-sensing (QS) molecules that regulate biological processes such as biofilm formation and intra- or interspecies communication appear to be good candidates. The invitro antibiotic-adjuvant effects of QS molecules diffusible signal factor (DSF) and B. cenocepacia producing-DSF (BDSF) were investigated against mature Staphylococcal biofilms. Broth microdilution methods were used for the determinations of MIC, MBC, MBIC, and MBEC, and bactericidal activities were determined by TKC method. The lowest MICs were obtained with ciprofloxacin and gentamicin, and MBECs with ciprofloxacin. DSF and BDSF at 0.5 µM decreased the MICs as 2–8, and 2–32 fold, respectively. In TKC studies, –cidal activities were achieved by BDSF + gentamycin, or ciprofloxacin, and DSF + daptomycin, vancomycin, meropenem or gentamycin combinations. Synergistic effects were generally obtained with BDSF + gentamicin combinations, followed by DSF + daptomycin against most S. aureus; while BDSF + gentamicin or ciprofloxacin, and DSF + vancomycin or meropenem were synergist against some S. epidermidis biofilms. Also, the antagonist effects were observed with BDSF + meropenem or ciprofloxacin against each MSSE and MSSA. It is estimated that these QS molecules, although it was strain dependent, generally enhanced the antibiotic activity, and would be a new and effective treatment strategy for biofilm control, either alone or as an antibiotic adjuvant.en_US
dc.description.sponsorshipIstanbul University -- 54406en_US
dc.identifier.citationBilgin, M., Döşler, S., & Ötük, G. (2024). Antibiotic adjuvant activities of quorum sensing signal molecules DSF and BDSF against mature biofilms of Staphylococci. Journal of Chemotherapy, 36(1), pp. 11-23. https://doi.org/10.1080/1120009X.2023.2270743en_US
dc.identifier.doi10.1080/1120009X.2023.2270743en_US
dc.identifier.endpage23en_US
dc.identifier.issn1120-009X
dc.identifier.issue1en_US
dc.identifier.pmidPMID: 37873740en_US
dc.identifier.scopus2-s2.0-85144642045en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.1080/1120009X.2023.2270743
dc.identifier.urihttps://hdl.handle.net/20.500.13055/566
dc.identifier.volume36en_US
dc.identifier.wosWOS:001091717400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorBilgin, Merve
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofJournal of Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibiofilm Activityen_US
dc.subjectBDSFen_US
dc.subjectDSFen_US
dc.subjectQS Signal Moleculesen_US
dc.subjectS. Aureusen_US
dc.subjectS. Epidermidisen_US
dc.titleAntibiotic adjuvant activities of quorum sensing signal molecules DSF and BDSF against mature biofilms of Staphylococcien_US
dc.typeArticleen_US
dspace.entity.typePublication

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