Determination of the toxicity preferences of ocular drug delivery system by comparing two different toxicity bioassays

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dc.authorid0000-0001-6212-2706en_US
dc.authorscopusid57194855634en_US
dc.authorwosidP-2971-2019en_US
dc.contributor.authorÜner, Burcu
dc.contributor.authorDurgun, Meltem Ezgi
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorTaş, Çetin
dc.contributor.authorÜner, Melike
dc.contributor.authorÖzsoy, Yıldız
dc.date.accessioned2023-10-18T11:10:48Z
dc.date.available2023-10-18T11:10:48Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractOcular drug delivery methods are highly favored for boosting bioavailability, patient compliance, and lower adverse effects and dose frequency. In addition to preventing adverse effects from the active ingredient, the parts of drug delivery systems must be nontoxic and nonallergic as well. Mitochondrial toxicity test (MTT) and Hen's egg chorioallantois membrane (HET-CAM) assay are the most often utilized tests based on this dilemma. The toxicity of loteprednol etabonate loaded solid lipid nanoparticles, lipid nanostructured carriers, and nanoemulsion were compared. Oleic acid, Precirol®ATO5, and Pluronic® F68 were used in the preparation. Their toxicities were evaluated by using two different toxicity tests (MTT and HET-CAM). The results suggest that there are no significant differences between the HET-CAM and MTT assays. It is noteworthy that the HET-CAM assay offers a more cost-effective and environmentally friendly alternative to the MTT assay, as it does not require cell culture and generates less toxic waste. This information may be useful to consider when selecting between the two assays.en_US
dc.identifier.citationÜner, B., Durgun, M. E., Özdemir, S., Taş, Ç., Üner, M., & Özsoy, Y. (2023). Determination of the toxicity preferences of ocular drug delivery system by comparing two different toxicity bioassays. Assay and Drug Development Technologies, 21(7), pp. 337-343. https://doi.org/10.1089/adt.2023.058en_US
dc.identifier.doi10.1089/adt.2023.058en_US
dc.identifier.endpage343en_US
dc.identifier.issn1540-658X
dc.identifier.issn1557-8127
dc.identifier.issue7en_US
dc.identifier.pmidPMID: 37831907en_US
dc.identifier.scopus2-s2.0-85175586500en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage337en_US
dc.identifier.urihttps://doi.org/10.1089/adt.2023.058
dc.identifier.urihttps://hdl.handle.net/20.500.13055/563
dc.identifier.volume21en_US
dc.identifier.wosWOS:001083097100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖzdemir, Samet
dc.language.isoenen_US
dc.publisherMary Ann Lieberten_US
dc.relation.ispartofASSAY and Drug Development Technologiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHET-CAMen_US
dc.subjectMTTen_US
dc.subjectNanoparticular Deliveryen_US
dc.subjectOcular Targetingen_US
dc.titleDetermination of the toxicity preferences of ocular drug delivery system by comparing two different toxicity bioassaysen_US
dc.typeArticleen_US
dspace.entity.typePublication

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