Cognitive impairment in Parkinson’s disease: An updated overview focusing on emerging pharmaceutical treatment approaches

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dc.authorid0000-0002-8584-5488en_US
dc.authorscopusid24398298200en_US
dc.authorwosidEQE-8550-2022en_US
dc.contributor.authorDeğirmenci, Yıldız
dc.contributor.authorAngelopoulou, Efthalia
dc.contributor.authorGeorgakopoulou, Vasiliki Epameinondas
dc.contributor.authorBougea, Anastasia
dc.date.accessioned2023-08-29T08:54:37Z
dc.date.available2023-08-29T08:54:37Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.description.abstractCognitive impairment in patients with Parkinson’s disease (PD), which may occur in various severities, represents one of the commonest and most disabling non-motor manifestations during the course of the disease, causing a negative impact on patients’ quality of life. Eventually, it becomes a burden for the family members and/or the caregivers of patients, as it progresses to PD dementia. Current pharmacological treatments for cognitive impairment in PD exhibit partial efficacy, while novel effective therapeutic strategies are required. Accumulating preclinical and clinical evidence shows that several agents may provide beneficial effects on patients with PD and cognitive impairment, including ceftriaxone, ambroxol, intranasal insulin, nilotinib, atomoxetine, mevidalen, blarcamesine, prasinezumab, SYN120, ENT-01, NYX-458, GRF6021, fosgonimeton, INT777, Neuropeptide S, silibinin, osmotin, cordycepin, huperzine A, fibroblast growth factor 21, Poloxamer 188, ginsenoside Rb1, thioredoxin-1, tangeretin, istradefylline, and Eugenia uniflora. Potential underlying mechanisms include the inhibition of a-synuclein aggregation, improvement of mitochondrial function, regulation of synaptic plasticity, impact on gut-brain axis, modulation of neuroinflammation, upregulation of neurotrophic factors, as well as cholinergic, dopaminergic, serotoninergic and norepinephrine neurotransmission. In this overview, we aim to cover the clinical aspects of PD associated cognitive impairment, highlighting recent evidence on emerging treatment approaches that are currently under investigation at a preclinical and clinical level.en_US
dc.identifier.citationDeğirmenci, Y., Angelopoulou, E., Georgakopoulou, V. E., & Bougea, A. (2023). Cognitive impairment in Parkinson’s disease: An updated overview focusing on emerging pharmaceutical treatment approaches. Medicina, 59(10), pp. 1-17. https://doi.org/10.20944/preprints202308.1550.v1en_US
dc.identifier.doi10.20944/preprints202308.1550.v1en_US
dc.identifier.endpage17en_US
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144en_US
dc.identifier.issue10en_US
dc.identifier.pmidPMID: 37893474en_US
dc.identifier.scopus2-s2.0-85175278705en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.20944/preprints202308.1550.v1
dc.identifier.urihttps://hdl.handle.net/20.500.13055/534
dc.identifier.volume59en_US
dc.identifier.wosWOS:001119392200001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDeğirmenci, Yıldız
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMedicinaen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectParkinson's Diseaseen_US
dc.subjectCognitionen_US
dc.subjectDementiaen_US
dc.subjectCognitive Declineen_US
dc.titleCognitive impairment in Parkinson’s disease: An updated overview focusing on emerging pharmaceutical treatment approachesen_US
dc.typeReview Articleen_US
dspace.entity.typePublication

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