Evaluation of serum placenta-specific gene 8 protein, total antioxidant capacity, interleukin-10, interleukin-17A, interleukin-21 and interleukin-33 levels in Turkish women with gestational diabetes mellitus

Basit Öğe Kaydı
dc.authorid0000-0002-6424-7411en_US
dc.authorscopusid57366670900en_US
dc.authorwosidCJT-9277-2022en_US
dc.contributor.authorÇıracı, Enver
dc.contributor.authorElgün, Tuğba
dc.contributor.authorGök Yurttaş, Asiye
dc.contributor.authorÇağın Kuzey, Hazel
dc.contributor.authorEkenoğlu Merdan, Yağmur
dc.contributor.authorToprak, Muhammed Sait
dc.contributor.authorTetik, Sermin
dc.date.accessioned2024-01-10T08:27:50Z
dc.date.available2024-01-10T08:27:50Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalıen_US
dc.description.abstractPurpose: Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance that begins or is diagnosed during pregnancy. Our study aimed to establish a correlation between proin flammatory and anti-inflammatory response in order to be able to develop treatment strategies and determine early diagnosis biomarkers in the sera of cases diagnosed with GDM. Moreover, we aimed to investigate interleukin (IL), placenta-specific gene 8 protein (PLAC8) and total antioxidant capacity (TAC) in patients with GDM. Methods: A total of 121 patients were included in the study. These were divided into four patient groups: pregnant and diagnosed with DM (P-GDM, n = 30); pregnant and not diagnosed with DM (P-NGDM, n = 32); non-pregnant diagnosed with DM (NP-DM, n = 29) and non-pregnant and not diagnosed with DM (NPNDM, n = 30). IL-10, IL-17A, IL-21, IL-33, PLAC8 and TAC determinations from patients were evaluated by ELISA (Enzyme-Linked ImmunoSorbent Assay) method. Results: IL-10 and IL-33 concentrations were found to be significantly higher in P-GDM and NP DM patient groups compared to P-NGDM and NP-NDM groups (p < 0.001). The PLAC8 level in the P GDM patient group (20.38 ± 5.37) was determined to be significantly higher than in the P-NGDM patient group (3.41 ± 2.17, p < 0.001). TAC in the P-NGDM and NP-NDM groups (12.42 ± 2.31 vs. 12.96 ± 3.78, p < 0.001) was determined to be significantly higher than in the P-GDM and NP-DM groups (4.8 ± 0.52 vs. 2.21 ± 0.71, p < 0.001). Discussion: The fact that the importance of PLAC8 level and TAC in the diagnosis and follow-up of GDM in pregnancy is demonstrated for the first time in this study shows that it is unique.en_US
dc.description.abstractObjetivo La diabetes mellitus gestacional (DMG) se define como una intolerancia a los carbohidratos que comienza o se diagnostica durante el embarazo. El objetivo de nuestro estudio consistió en proporcionar una correlación entre la respuesta proinflamatoria e inflamatoria para desarrollar estrategias de tratamiento y determinar biomarcadores séricos diagnósticos tempranos en las mujeres con DMG. Además, pretendíamos investigar la interleucina (IL), la proteína del gen 8 específica de la placenta (PLAC8) y la actividad antioxidante total (AAT) de las pacientes con DMG. Métodos En el estudio se incluyó a un total de 121 pacientes. Hubo cuatro grupos: embarazadas y con diagnóstico de DMG (E-DMG, n = 30), embarazadas y sin DMG (E-NDMG, n = 32); no embarazadas con DMG (NE-DMG, n = 29) y no embarazadas y sin DMG (NE-NDMG, n = 30). Las determinaciones de IL-10, IL-17A, IL-21, IL-33, PLAC8 y la AAT de las mujeres se evaluaron mediante el método ELISA (prueba de inmunoadsorción enzimática). Resultados Se observó que las concentraciones de IL-10 e IL-33 eran significativamente superiores en los grupos de pacientes E-DMG y NE-DMG en comparación con los de E-NDMG y NE-NDMG (p < 0,001). La concentración de PLAC8 en el grupo de E-DMG (20,38 ± 5,37) era significativamente superior que en el de E-NDMG (3,41 ± 2,17) (p < 0,001). La AAT en los grupos de E-NDMG y NE-NDMG (12,42 ± 2,31 vs. 12,96 ± 3,78, p < 0,001) era significativamente mayor que en los de E-DMG y NE-DMG (4,8 ± 0,52 vs. 2,21 ± 0,71, p < 0,001). Discusión En este estudio se ha demostrado por primera vez la importancia de la concentración de PLAC8 y de la AAT en el diagnóstico y seguimiento de la DMG en el embarazo, lo que lo convierte en un trabajo sin precedentes.en_US
dc.description.sponsorshipBu çalışma Araştırma Fonu tarafından desteklenmiştir. Biruni Üniversitesi. Proje Numarası: Biruni-BAP-2020-01-30 ve Tübitak 1002 Proje Numarası: 123S102en_US
dc.identifier.citationÇıracı, E., Elgün, T., Gök Yurttaş, A., Çağın Kuzey, H., Ekenoğlu Merdan, Y., Toprak, M. S., & Tetik, S. (2024). Evaluation of serum placenta-specific gene 8 protein, total antioxidant capacity, interleukin-10, interleukin-17A, interleukin-21 and interleukin-33 levels in Turkish women with gestational diabetes mellitus. Endocrinología, Diabetes y Nutrición, 71(1), pp. 12-18. https://doi.org/10.1016/j.endinu.2023.11.006.en_US
dc.identifier.doi10.1016/j.endinu.2023.11.006en_US
dc.identifier.endpage18en_US
dc.identifier.issn2530-0164
dc.identifier.issn2530-0172
dc.identifier.issn2530-0180en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85182249460en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage12en_US
dc.identifier.urihttps://doi.org/10.1016/j.endinu.2023.11.006
dc.identifier.urihttps://hdl.handle.net/20.500.13055/625
dc.identifier.volume71en_US
dc.identifier.wosWOS:001188812100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorGök Yurttaş, Asiye
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEndocrinología, Diabetes y Nutriciónen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGestational Diabetes Mellitusen_US
dc.subjectCytokinesen_US
dc.subjectBiomarkersen_US
dc.subjectPLAC8en_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectDiabetes Mellitus Gestacionalen_US
dc.subjectCitocinasen_US
dc.subjectBiomarcadoresen_US
dc.subjectActividad Antioxidante Totalen_US
dc.titleEvaluation of serum placenta-specific gene 8 protein, total antioxidant capacity, interleukin-10, interleukin-17A, interleukin-21 and interleukin-33 levels in Turkish women with gestational diabetes mellitusen_US
dc.title.alternativeEvaluación de los niveles séricos de proteína del gen 8 específico de la placenta, capacidad antioxidante total, interleucina-10, interleucina-17A, interleucina-21 e interleucina-33 en mujeres turcas con diabetes mellitus gestacionalen_US
dc.typeArticleen_US
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
Evaluation of serum placenta-specific gene 8 protein, total antioxidant capacity, interleukin-10, interleukin-17A, interleukin-21 and interleukin-33 levels in.pdf
Boyut:
429.99 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Biyokimya Ana Bilim Dalı Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu