Choline or CDP-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally-Induced endotoxic shock

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dc.authorid0000-0003-0532-789Xen_US
dc.authorscopusid35741320500en_US
dc.authorwosidAAL-8873-2021en_US
dc.contributor.authorKocatürk, Meriç
dc.contributor.authorYılmaz, Zeki
dc.contributor.authorCansev, Mehmet
dc.contributor.authorÖzarda, Yeşim
dc.contributor.authorCeron, Jose Joaquin
dc.contributor.authorButurak, Ali
dc.contributor.authorUlus, İsmail Hakkı
dc.date.accessioned2021-12-20T07:54:42Z
dc.date.available2021-12-20T07:54:42Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractEndotoxin shock is associated with severe impairments in cardiovascular and respiratory functions. We showed previously that choline or cytidine-5 '-diphosphocholine (CDP-choline) provides beneficial effects in experimental endotoxin shock in dogs. The objective of the present study was to determine the effects of choline or CDPcholine on endotoxin-induced cardiovascular and respiratory dysfunctions. Dogs were treated intravenously (i.v.) with saline or endotoxin (LPS, 0.1 mg/kg) 5 min before i.v. infusion of saline, choline (20 mg/kg) or CDP-choline (70 mg/kg). Blood pressure, cardiac rate, myocardial and left ventricular functions, respiratory rate, blood gases, serum electrolytes and cardiac injury markers were determined before and at 0.5-48 h after endotoxin. Plasma tumor necrosis factor alpha (TNF-alpha), high mobility group box-1 (HMGB1), catecholamine and nitric oxide (NO) levels were measured 2 h and 24 h after the treatments. Endotoxin caused immediate and sustained reductions in blood pressure, cardiac output, pO2 and pH; changes in left ventricular functions, structure and volume parameters; and elevations in heart rate, respiratory rate, pCO2 and serum electrolytes (Na, K, Cl, Ca and P). Endotoxin also resulted in elevations in blood levels of cardiac injury markers, TNF-alpha, HMGB1, catecholamine and NO. In choline- or CDP-choline-treated dogs, all endotoxin effects were much smaller in magnitude and shorter in duration than observed values in controls. These data show that treatment with choline or CDP-choline improves functions of cardiovascular and respiratory systems in experimental endotoxemia and suggest that they may be useful in treatment of endotoxin shock in clinical setting.en_US
dc.identifier.citationKocatürk, M., Yılmaz, Z., Cansev, M., Özarda, Y., Ceron, J. J., Buturak, A., & Ulus, İ. H. (2021). Choline or CDP-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally – Induced endotoxic shock. Research in Veterinary Science, 141, pp. 116-128. https://doi.org/10.1016/j.rvsc.2021.10.010en_US
dc.identifier.doi10.1016/j.rvsc.2021.10.010en_US
dc.identifier.endpage128en_US
dc.identifier.pmidPMID: 34715589en_US
dc.identifier.scopus2-s2.0-85117934856en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage116en_US
dc.identifier.urihttps://doi.org/10.1016/j.rvsc.2021.10.010
dc.identifier.urihttps://hdl.handle.net/20.500.13055/94
dc.identifier.volume141en_US
dc.identifier.wosWOS:000714142900010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖzarda, Yeşim
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofResearch in Veterinary Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholineen_US
dc.subjectEndotoxemiaen_US
dc.subjectSepsisen_US
dc.subjectCardiopulmonary functionen_US
dc.subjectDogsen_US
dc.titleCholine or CDP-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally-Induced endotoxic shocken_US
dc.typeArticleen_US
dspace.entity.typePublication

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