Determination of the relationship between CD34+ stem cell amount and DMSO in hematopoetic stem cell transplantation

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dc.authorid0000-0002-0335-2330en_US
dc.authorscopusid57478196200en_US
dc.authorwosidHIR-7894-2022en_US
dc.contributor.authorMeriç, Neslihan
dc.contributor.authorParmaksız, Ayhan
dc.contributor.authorGülbaş, Zafer
dc.date.accessioned2023-04-10T07:20:19Z
dc.date.available2023-04-10T07:20:19Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalıen_US
dc.description.abstractIt is important to calculate the CD34+ stem cell (SC) count at the right time in patients with hematological malignancies who will undergo Hematopoietic Stem Cell Transplantation (HSCT). The amount of SC infused into the patient affects the engraftment time and healing process of the patient. In this study, we aimed to compare which of the DMSO-not removed and DMSO-removed samples showed the CD34 + SC amount more accurately as the SC amount determination method after the SC was dissolved after cryopreservation in patients who will undergo HSCT. A total of 22 patients were included in the study. All 22 patients were transplanted from frozen samples using DMSO. After the SC products were dissolved in a 37 °C water bath, they were washed 2 times and the amount of CD34+ SC was studied from the samples taken by removing DMSO and without removing DMSO. In the findings, the amounts of CD34+ SC studied with both methods were compared. The increase in the number and percentage of CD34+ SC after DMSO-removed was found to be statistically significant both in terms of difference and proportionally, and the calculated effect sizes also showed that the increase was clinically significant (Cohen's d is between 0.43 and 0.677). After thawing the frozen SCs of the patients who will undergo HSCT, the analysis of CD34+ SCs from which DMSO is removed provides a more accurate calculation of the CD34+ SC amount in the AP.en_US
dc.identifier.citationMeriç, N., Parmaksız, A., & Gülbaş, Z. (2023). Determination of the relationship between CD34+ stem cell amount and DMSO in hematopoetic stem cell transplantation. Transplant Immunology, 78, pp. 1-5. https://doi.org/10.1016/j.trim.2023.101831en_US
dc.identifier.doi10.1016/j.trim.2023.101831en_US
dc.identifier.endpage5en_US
dc.identifier.issn0966-3274
dc.identifier.issn1878-5492
dc.identifier.pmidPMID: 37019290en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.trim.2023.101831
dc.identifier.urihttps://hdl.handle.net/20.500.13055/440
dc.identifier.volume78en_US
dc.identifier.wosWOS:000984653800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorParmaksız, Ayhan
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofTransplant Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApheresis Product (AP)en_US
dc.subjectCD34+ Scs Counten_US
dc.subjectCryopreservationen_US
dc.subjectDMSO (Dimethyl Sulfoxide)en_US
dc.subjectHematopoietic Stem Cell Transplantation (HSCT)en_US
dc.titleDetermination of the relationship between CD34+ stem cell amount and DMSO in hematopoetic stem cell transplantationen_US
dc.typeArticleen_US
dspace.entity.typePublication

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