Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: an animal study

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dc.authorid0000-0002-4553-2655en_US
dc.authorscopusid46861254600en_US
dc.contributor.authorAksoy, Nilay
dc.contributor.authorŞen, Emine
dc.contributor.authorSukmasari, Susi
dc.contributor.authorBingöl Özakpınar, Özlem
dc.contributor.authorArıcıoğlu, Feyza
dc.contributor.authorYücel, Yasemin Yücel
dc.contributor.authorDumlu, Muhammet Rıdvan
dc.contributor.authorDoolaanea, Abd Almonem
dc.contributor.authorAbdul Rahman, Mohammad Nasrin
dc.contributor.authorOlgaç, Vakur
dc.contributor.authorBozkan, Pırıl
dc.contributor.authorÖzen, Buğra
dc.date.accessioned2022-06-01T06:34:07Z
dc.date.available2022-06-01T06:34:07Z
dc.date.issued2022en_US
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü, Pedodonti Ana Bilim Dalıen_US
dc.description.abstractPurpose The study aimed to evaluate the possible preventive effect of two concentrations (3 and 5% w/w) of Eugenia jambolana (EJ) extract against 5-FU-induced mucositis. Method Sixteen adult rats were separated into four groups: two control and two preventive groups. Animals in Groups 1, 2, and 3 were injected intraperitoneally with 60 mg/kg/day of 5-FU on Day 1 followed by 150 mg/kg/day on Day 5. The rats in Group 4 (negative control) were given physiological saline at the same times and doses. Furthermore, on the fifth day of the study, the cheek and sublingual mucosa were irritated by external superficial scratches using the tip of an 18-G needle, followed by the application 15 µL of 20% acetic acid, after which 3 and 5% EJ w/w gels were applied topically for animals in Groups 2 and 3, respectively. Results The weight and the mucositis scores were recorded. Antioxidant and anti-inflammatory markers and biochemical tests were analyzed. Significant differences were found between the study groups in weight loss, clinical mucositis scores, mortality rates, and antioxidant and anti-inflammatory parameters. Conclusion The preventive effect of 3% gel was significant, with no mortality rate, making it an option for preventive strategies.en_US
dc.identifier.citationAksoy, N., Sen, E., Sukmasari, S., Özakpınar, Ö. B., Arıcıoğlu, F., Yücel, Y. Y., Dumlu, M. R., Doolaanea, A. A., AbdulRahman, M. N., Olgac, V., Bozkan, P. & Ozan, B. (2022). Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: an animal study. Journal of Cancer Research and Clinical Oncology, 148(8), 2153-2162. https://doi.org/10.1007/s00432-022-04065-3en_US
dc.identifier.doi10.1007/s00432-022-04065-3en_US
dc.identifier.endpage2162en_US
dc.identifier.issue8en_US
dc.identifier.pmidPMID: 35622166en_US
dc.identifier.scopus2-s2.0-85130847543en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2153en_US
dc.identifier.urihttps://doi.org/10.1007/s00432-022-04065-3
dc.identifier.urihttps://hdl.handle.net/20.500.13055/222
dc.identifier.volume148en_US
dc.identifier.wosWOS:000800703000002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖzen, Buğra
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.hasversionIn this article the author name “Bugra Ozen” was incorrectly written as “Bugra Ozan” -- WOS:000825374300005 -- https://doi.org/10.1007/s00432-022-04065-3
dc.relation.ispartofJournal of Cancer Research and Clinical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMucositisen_US
dc.subjectChemotherapyen_US
dc.subjectEugenia jambolanaen_US
dc.subjectAntioxidanten_US
dc.subjectAnti-infammatoryen_US
dc.subjectGelen_US
dc.titleInvestigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: an animal studyen_US
dc.typeArticleen_US
dspace.entity.typePublication

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