Evaluation of seropositivity developed against specific antigens of helicobacter pylori in neurodegenerative diseases

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dc.authorid0000-0002-6993-0383
dc.authorid0000-0002-9851-7002
dc.authorid0000-0002-7172-954X
dc.authorid0000-0003-2808-9353
dc.authorid0000-0002-3501-5160
dc.authorid0000-0001-5815-6700
dc.authorid0000-0002-1598-5944
dc.authorid0000-0001-7967-3539
dc.authorid0000-0003-3628-7392
dc.authorid0000-0002-4549-3887
dc.authorid0000-0003-1072-3846
dc.contributor.authorAkçin, Rüveyda
dc.contributor.authorTütüncü, Melih
dc.contributor.authorKaragöz Sakallı, Nazan
dc.contributor.authorApaydın, Hülya
dc.contributor.authorBozluolçay, Melda
dc.contributor.authorCan, Günay
dc.contributor.authorSoysal, Aysun
dc.contributor.authorSirekbasan, Serhat
dc.contributor.authorDinç, Harika Öykü
dc.contributor.authorSarıbaş, Suat
dc.contributor.authorKocazeybek, Bekir
dc.date.accessioned2026-02-10T08:25:16Z
dc.date.available2026-02-10T08:25:16Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractIntroduction: It is suggested that Helicobacter pylori (Hp) can reach the brain via the oral-nasal-olfactory route, through Hp-infected monocytes in the disrupted blood-brain barrier (BBB), or through a rapid retrograde neural network leading to neurodegeneration from the gastrointestinal tract (GIS) and may lead to neurodegenerative diseases such as Alzheimer’s (AD), Parkinson’s (PD) and Multiple sclerosis (MS). In this study, we aimed to evaluate the possible immunopathogenesis relationship between Hp-specific antigens and neurodegenerative diseases by determining the frequency of seropositivity against different specific antigens of Hp in diseases such as AD, PD and MS. Methods: In our cross-sectional, retrospective case-control study, the immunoreactivity frequencies of Hp-specific and non-specific CagA (p120), VacA (p95), p75, FSH (p67), UreB (p66), HSP homolog (p57), flagellin (p54), p50, p41, p33, OMP (p30), UreA (p29), p26, OMP (p19), p17 antigens were determined by Western Blot method in 36 AD, 35 PD, 91 MS cases with Hp-IgG reactivity, and 55 controls without a neurodegenerative/demyelinating by ELISA method. Results: No significant difference was found between the immunoreactivity frequencies of Hp antigens between AD and control groups (p>0.05). In the multivariate logistic analysis performed for PD cases, age ≥ 50 and immunoreactivity frequency of p19 were found to be independent risk factors (OR: 36.752, p<0.05) (OR: 5.570, p<0.05). In MS cases, immunoreactivity frequency of p17 antigen was found to be a risk factor (OR: 2.646, p<0.05). In addition, the mean level of Hp-IgG reactivity was found to be negatively associated with MS development (indicating an inverse correlation) in the control group compared to the MS group (OR: 0.585, p < 0.05). Furthermore, logistic regression analysis in the total study group revealed that the immunoreactivity frequency of the p17 antigen was identified as a risk factor for MS (OR: 2.438, p<0.05). Conclusion: Our data on AD cases are insufficient. In PD cases, the significantly higher frequency of immunoreactivity to the Hp-p19 antigen in individuals aged ≥50 years (OR=5.570) is noteworthy. In the MS group, the significantly high detection of Hp p17 antigen and its presence as a risk factor (OR=2.646), and the significantly high detection of p26 antigen suggest the relationship between these antigens and the MS development process. However, it is a fact that new and many prospective cohort-based case-control studies are needed to reveal this more clearly.
dc.description.sponsorshipThis study was supported by the İstanbul University- Cerrahpaşa Scientific Research Projects Unit. Project No: TYL-2021-36048 Bu çalışma İstanbul Üniversitesi-Cerrahpaşa Bilimsel Araştırma Projeleri Birimi tarafından desteklenmiştir. Proje No: TYL-2021-36048
dc.identifier.citationAkçin, R., Tütüncü, M., Karagöz Sakallı, N., Apaydın, H., Bozluolçay, M., Can, G., Soysal, A., Sirekbasan, S., Dinç, H. Ö., Sarıbaş, S., & Kocazeybek, B. (2026). Evaluation of seropositivity developed against specific antigens of helicobacter pylori in neurodegenerative diseases. Archives of Neuropsychiatry, 63, pp. 65-72. https://doi.org/10.29399/npa.29038
dc.identifier.doi10.29399/npa.29038
dc.identifier.endpage72
dc.identifier.issn1309-4866
dc.identifier.pmidPMID: 41613025
dc.identifier.scopusqualityQ3
dc.identifier.startpage65
dc.identifier.urihttps://doi.org/10.29399/npa.29038
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1309
dc.identifier.volume63
dc.identifier.wosWOS:001674169700011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorAkçin, Rüveyda
dc.institutionauthorid0000-0002-6993-0383
dc.language.isoen
dc.publisherTurkish Neuropsychiatric Society
dc.relation.ispartofArchives of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer’s Disease
dc.subjectHelicobacter Pylori
dc.subjectMultiple Sclerosis
dc.subjectParkinson’s Disease
dc.titleEvaluation of seropositivity developed against specific antigens of helicobacter pylori in neurodegenerative diseases
dc.title.alternativeNörodejeneratif hastalıklarda helicobacter pylori’nin spesifik farklı antijenlerine karşı gelişen seropozitifliğin araştırılması ve önemi
dc.typeArticle
dspace.entity.typePublication

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