Sun-macerated hypericum perforatum oleates in fixed oils: Analytical characterization and comparative wound-healing activity

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dc.authorid0009-0007-7864-7137
dc.authorid0000-0002-5829-7869
dc.authorid0000-0001-6781-9983
dc.authorid0000-0002-0335-2330
dc.authorid0000-0002-9228-7963
dc.authorid0000-0002-1348-6033
dc.contributor.authorÇapar, Cihan
dc.contributor.authorKüpeli, Esra
dc.contributor.authorYaba, Aylin
dc.contributor.authorParmaksız, Ayhan
dc.contributor.authorSümer, Engin
dc.contributor.authorYeşilada, Erdem
dc.date.accessioned2026-04-21T13:32:10Z
dc.date.available2026-04-21T13:32:10Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractBackground/aim: Hypericum perforatum L. oleates prepared in fixed oils have long been used for wound management due to their antiinflammatory, antibacterial, and tissue-regenerative properties. The bioactivity of these oleates is mainly attributed to hypericin, hyperforin, and pseudohypericin. In the present study, the wound-healing potential of H. perforatum oleates prepared in different fixed oils, including Olea europaea L. (olive), Sesamum indicum L. (sesame), Helianthus annuus L. (sunflower), and Nigella sativa L. (black seed), is compared. Materials and methods: Fixed oils were characterized by gas chromatography–mass spectrometry, while oleuropein (olive oil) and thymoquinone (black seed oil) were quantified by high-performance liquid chromatography, and sesamin and sesamol (sesame oil) by spectrophotometry. Oleates were prepared using the traditional sun maceration method. Hypericin, hyperforin, and pseudohypericin were quantified by liquid chromatography–mass spectrometry and ultraviolet spectrophotometry. In vitro and in vivo assays were performed to assess the wound-healing activities of both the fixed oils and their respective oleates. Results: All oleates exhibited significantly greater wound-healing activity than the corresponding fixed oils. The most pronounced synergistic effects were observed with the olive oil and sesame oil oleates. Conclusion: Maceration of H. perforatum in fixed oils enhances the intrinsic therapeutic properties of oils and contributes to improvements in multiple wound-healing parameters. The findings of the present study support the traditional use of H. perforatum oleates and provide a scientific basis for their pharmacological development.
dc.identifier.citationÇapar, C., Küpeli, E., Yaba, A., Parmaksız, A., Sümer, E., & Yeşilada, E. (2026). Sun-macerated hypericum perforatum oleates in fixed oils: Analytical characterization and comparative wound-healing activity. Turkish Journal of Medical Sciences, 56(2), pp. 570-584. https://doi.org/10.55730/1300-0144.6190
dc.identifier.doi10.55730/1300-0144.6190
dc.identifier.endpage584
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage570
dc.identifier.urihttps://doi.org/10.55730/1300-0144.6190
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1439
dc.identifier.volume56
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorParmaksız, Ayhan
dc.institutionauthorid0000-0002-0335-2330
dc.language.isoen
dc.publisherThe Scientific and Technological Research Council of Türkiye (TÜBİTAK)
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHypericum Perforatum
dc.subjectFixed Oils
dc.subjectOleates
dc.subjectFibroblast Migration
dc.subjectWound Healing
dc.titleSun-macerated hypericum perforatum oleates in fixed oils: Analytical characterization and comparative wound-healing activity
dc.typeArticle
dspace.entity.typePublication

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