Altered gut microbiota in patients with idiopathic Parkinson’s disease: an age–sex matched case–control study

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dc.authorid0000-0002-2727-7048en_US
dc.authorscopusid35757727300en_US
dc.authorwosidG-6735-2015en_US
dc.contributor.authorBabacan Yıldız, Gülşen
dc.contributor.authorKayacan, Zeynep Çiğdem
dc.contributor.authorKaracan, İlker
dc.contributor.authorSümbül, Bilge
dc.contributor.authorElibol, Birsen
dc.contributor.authorGelisin, Özlem
dc.contributor.authorAkgül, Özer
dc.date.accessioned2023-02-03T11:25:15Z
dc.date.available2023-02-03T11:25:15Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractObjective: The investigations related to how gut microbiota changes the brain-gut axis in idiopathic Parkinson's disease (PD) attract growing interest. We aimed to determine whether gut microbiota is altered in PD patients and whether non-motor symptoms of PD and disease duration had any relation with alterations of microbiota profiles among patients. Methods: Microbial taxa in stool samples obtained from 84 subjects (42-PD patients and 42-healthy spouses) were analyzed using 16S rRNA amplicon-sequencing. Results: We observed a significant decrease of Firmicutes and a significant increase of Verrucomicrobiota at the phylum level. At the family level, Lactobacillaceae and Akkermansiaceae were significantly increased and Coriobacteriales Incertae Sedis were significantly decreased in the PD patients compared to their healthy spouses. Genus level comparison inferred significant increase in abundance only in Lactobacillus while the abundance of Lachnospiraceae ND3007 group, Tyzzerella, Fusicatenibacter, Eubacterium hallii group and Ruminococcus gauvreauii group were all decreased. We determined that the abundance of Prevotella genus decreased, but not significantly in PD patients. In addition, we found differences in microbiota composition between patients with and without non-motor symptoms. Conclusion: We observed differences in gut microbiota composition between PD patients and their healthy spouses. Our findings suggest that disease duration influenced microbiota composition, which in turn influenced development of non-motor symptoms in PD. This study is the first in terms of both gut microbiota research in Turkish PD patients and the probable effect of microbiota on non-motor symptoms of PD.en_US
dc.description.sponsorshipTurkish Scientifc and Technical Council (TÜBITAK-118S704) Bezmialem Vakif University Scientifc Research Found (6.2017/53)en_US
dc.identifier.citationBabacan Yıldız, G., Kayacan, Z. Ç., Karacan, İ. Sümbül, B., Elibol, B., Gelisin, Ö. & Akgül, Ö. (2023). Altered gut microbiota in patients with idiopathic Parkinson’s disease: an age–sex matched case–control study. Acta Neurologica Belgica, 123(3), pp. 999-1009. https://doi.org/10.1007/s13760-023-02195-0en_US
dc.identifier.doi10.1007/s13760-023-02195-0en_US
dc.identifier.endpage1009en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue3en_US
dc.identifier.pmidPMID: 36719617en_US
dc.identifier.scopus2-s2.0-85147120728en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage999en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-023-02195-0
dc.identifier.urihttps://hdl.handle.net/20.500.13055/387
dc.identifier.volume123en_US
dc.identifier.wosWOS:000924153000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorKayacan, Zeynep Çiğdem
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ecinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/118S704
dc.relation.ispartofActa Neurologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject16S rRNA Sequencingen_US
dc.subjectGut Microbiotaen_US
dc.subjectNon-Motor Symptomsen_US
dc.subjectParkinson’s Diseaseen_US
dc.titleAltered gut microbiota in patients with idiopathic Parkinson’s disease: an age–sex matched case–control studyen_US
dc.typeArticleen_US
dspace.entity.typePublication

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