Can the reduction of cytokines stop the progression of sepsis?

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dc.authorid0000-0001-7860-6801en_US
dc.contributor.authorKoç, Suna
dc.contributor.authorÇelebi, Serdar
dc.contributor.authorHanikoğlu, Ferhat
dc.contributor.authorPolat, Yalçın
dc.contributor.authorBörkü Uysal, Betül
dc.contributor.authorDokur, Mehmet
dc.contributor.authorÖzer, Türkan
dc.contributor.authorYavuzer, Serap
dc.contributor.authorİslamoğlu, Mehmet Sami
dc.contributor.authorCengiz, Mahir
dc.contributor.authorVardar, Gökay
dc.contributor.authorKüpeli, İlke
dc.date.accessioned2022-02-22T09:23:57Z
dc.date.available2022-02-22T09:23:57Z
dc.date.issued2022en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Programıen_US
dc.description.abstractObjective In this study, we aimed to analyze the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in ICU patients diagnosed with sepsis or septic shock. Methods The levels of procalcitonin (PCT) and C-reactive protein (CRP), determined to be indicators of infection/sepsis, and the levels of interleukins (IL-6, IL-8, and IL-10) and tumor necrosis factor α (TNFα), deemed as indicators of the cytokine storm, were compared among 32 patients before and after the hemadsorption procedure. Results The hemadsorption significantly reduced the levels of IL-6, IL-8, IL-10, TNFα, PCT, CRP, Acute Physiology and Chronic Health Evaluation (APACHE) scores, mortality rate, and Sequential Organ Failure Assessment (SOFA) scores (p<0.05). APACHE scores and the mean predicted mortality rate (PMR) of the non-survivors measured before the procedure was significantly higher than those of survivors (p=0.002 for both). IL-10, APACHE scores, and the mortality rates determined before the hemadsorption procedure were deemed significant parameters to predict the mortality among all ICU patients (p<0.05). IL-10 levels ≤125.3 ng/L, APACHE score >30, and PMR >70.33 were significantly associated with the mortality rates of all patients, indicating that these three parameters determined before the hemadsorption may be good predictors of mortality among ICU patients with sepsis. Conclusion The progression of sepsis in ICU patients may be prevented with cytokine hemadsorption applied as an immunomodulator therapy.en_US
dc.identifier.citationKoç, S., Çelebi, S., Hanikoğlu, F., Polat, Y., Börkü Uysal, B., Dokur, M., Özer, T., Yavuzer, S., İslamoğlu, M. S., Cengiz, M., Vardar, G., & Küpeli, İ. (2022). Can the reduction of cytokines stop the progression of sepsis? Cureus Journal of Medical Science, 14(2), pp. 1-8. https://doi.org/10.7759/cureus.22325en_US
dc.identifier.doi10.7759/cureus.22325en_US
dc.identifier.endpage8en_US
dc.identifier.issue2en_US
dc.identifier.pmidPMID: 35317038en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.22325
dc.identifier.urihttps://hdl.handle.net/20.500.13055/156
dc.identifier.volume14en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Indexen_US
dc.institutionauthorVardar, Gökay
dc.language.isoenen_US
dc.publisherCureus, Inc.en_US
dc.relation.ispartofCureus Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntensive Careen_US
dc.subjectInterleukinen_US
dc.subjectMortalityen_US
dc.subjectCytokine Hemadsorptionen_US
dc.subjectSepsisen_US
dc.titleCan the reduction of cytokines stop the progression of sepsis?en_US
dc.typeArticleen_US
dspace.entity.typePublication

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