Colorectal cancers and microsatellite instability

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dc.authorid0000-0003-3979-9182
dc.authorid0000-0002-3925-7060
dc.authorid0000-0002-3139-8205
dc.authorid0000-0001-6985-9436
dc.authorid0009-0008-0921-6592
dc.authorid0000-0003-2758-5945
dc.authorid0000-0001-7900-5813
dc.authorid0000-0002-8919-0482
dc.contributor.authorEsmkhani, Sahra
dc.contributor.authorEmrem, Mustafa
dc.contributor.authorŞahin, Ali
dc.contributor.authorBabayev, Hüseyn
dc.contributor.authorZeyneloğlu, Can
dc.contributor.authorArdıçlı, Sena
dc.contributor.authorYazıcı, Hilal
dc.contributor.authorYazıcı, Hülya
dc.date.accessioned2024-12-26T07:55:34Z
dc.date.available2024-12-26T07:55:34Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractColorectal cancer (CRC) is a multifactorial disease arising from the complex interplay between genetic predisposition and environmental influences. Despite its widespread incidence globally, CRC demon strates favorable prognostic outcomes when detected at an early stage. Microsatellite instability (MSI) is a common molecular abnormality associated with colorectal tumorigenesis. This review provides a comprehensive analysis of the molecular mechanisms, clinical implications, therapeutic approaches, and immune system interactions in MSI-associated CRC (MSI-CRC). Molecular changes include DNA slippage, dysfunction in the DNA mismatch repair (dMMR) system, and genetic/epigenetic factors that contribute to MSI. Clinically, MSI-CRC is characterized by distinct phenotypic features, including associations with Lynch syndrome, specific diagnostic methodologies, and prognostic relevance. The therapeutic landscape highlights the promising efficacy of immunotherapies and targeted treatments, particularly in dMMR–MSI-H-CRC. Immune dynamics within the tumor microenvironment (TME) reveal patterns of immune infiltration, immune evasion strategies, and opportunities to enhance the effectiveness of immunotherapy. Understanding these interrelated aspects is critical for developing tai lored therapeutic strategies and improving patient outcomes in MSI-CRC
dc.identifier.citationEsmkhani, S., Emrem, M., Şahin, A., Babayev, H., Zeyneloğlu, C., Ardıçlı, S., Yazıcı, H., & Yazıcı, H. (2024). Colorectal cancers and microsatellite instability. Turkish Journal of Oncology. 40(1), pp. 83-94. https://doi.org/10.5505/tjo.2024.4477
dc.identifier.doi10.5505/tjo.2024.4477
dc.identifier.endpage94
dc.identifier.issn2717-8978
dc.identifier.issn1300-7467
dc.identifier.issue1
dc.identifier.scopusqualityQ4
dc.identifier.startpage83
dc.identifier.urihttps://doi.org/10.5505/tjo.2024.4477
dc.identifier.urihttps://hdl.handle.net/20.500.13055/872
dc.identifier.volume40
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Index
dc.institutionauthorYazıcı, Hülya
dc.institutionauthorid0000-0002-8919-0482
dc.language.isoen
dc.publisherTürk Radyasyon Onkolojisi Derneği
dc.relation.ispartofTurkish Journal of Oncology
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiomarkers
dc.subjectColon Carcinoma
dc.subjectİnstability
dc.subjectMicrosatellite
dc.subjectStability
dc.titleColorectal cancers and microsatellite instability
dc.typeReview Article
dspace.entity.typePublication

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