The apoptotic efficacy of succinic acid on renal cancer cell lines

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dc.authorid0000-0003-3465-1808en_US
dc.authorscopusid57198446979en_US
dc.authorwosidS-9157-2017en_US
dc.contributor.authorKaşarcı, Göksu
dc.contributor.authorErtuğrul, Barış
dc.contributor.authorİplik, Elif Sinem
dc.contributor.authorÇakmakoğlu, Bedia
dc.date.accessioned2022-01-06T13:39:02Z
dc.date.available2022-01-06T13:39:02Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractRecently, studies on the effects of non-toxic substances on cancer prophylaxis have gained value as an alternative to existing treatment options. Current studies have shown that succinic acid or its derivatives exhibit anticancer activity by inducing apoptosis. We aimed to investigate the anticancer activity of succinic acid on renal cancer for the first time in the literature. The cytotoxic activity of succinic acid on CAKI-2 and ACHN as renal cancer cell lines and MRC-5 as a healthy cell line was determined using the WST-1 cytotoxicity test. Apoptotic activity was measured by Annexin V test and cell death ELISA kit. The results showed that 25 mu M and 50 mu M doses of succinic acid for 24 h remarkably reduced the cell viability for CAKI-2 cells (89.77% and 90.77%) and ACHN cells (41.57% and 54.54%). Also, no significant effect was observed on the healthy cell line, as we expected. Additionally, administration of succinic acid at same doses resulted in apoptotic activity for ACHN cells (19.1 and 12.7) and CAKI-2 cells (19.85 and 29.55). ELISA results with same doses of succinic acid treatment increased the apoptotic fragment rates by 4.7 and 2.13-fold in CAKI-2 cells, and 32.92, 12.7-fold in ACHN cells. Succinic acid is a focal point for cancer treatments not only for its apoptotic success on cancer cells but also for its capacity to be metabolically active for humans. Our results suggest that succinic acid could be a potential therapeutic agent for individual cancer treatment approaches together with further molecular research.en_US
dc.identifier.citationKasarci, G., Ertugrul, B., Iplik, E. S., & Cakmakoglu, B. (Dec 2021). The apoptotic efficacy of succinic acid on renal cancer cell lines. Medical Oncology, 38(12), 1-8. https://doi.org/10.1007/s12032-021-01577-9en_US
dc.identifier.doi10.1007/s12032-021-01577-9en_US
dc.identifier.endpage8en_US
dc.identifier.issue12en_US
dc.identifier.pmidPMID: 34687367en_US
dc.identifier.scopus2-s2.0-85117721366en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-021-01577-9
dc.identifier.urihttps://hdl.handle.net/20.500.13055/126
dc.identifier.volume38en_US
dc.identifier.wosWOS:000710216200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorİplik, Elif Sinem
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSuccinic aciden_US
dc.subjectRenal cell carcinomaen_US
dc.subjectApoptosisen_US
dc.subjectAnticanceren_US
dc.subjectCell cultureen_US
dc.titleThe apoptotic efficacy of succinic acid on renal cancer cell linesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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