In vitro antileishmanial activity of Lavandula angustifolia essential oil on leishmania infantum parasites
Yükleniyor...
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Istanbul University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Leishmaniasis is an endemic tropical disease that is disseminated through the bite of a sandfly infected with Leishmania parasites. Conventional antileishmanial drugs are mainly toxic and can be ineffective; therefore, there is a need for new natural drug candidates. This study investigated the antileishmanial effects of Lavandula angustifolia (LA) essential oil on Leishmania infantum (L. infantum) parasites, and the safety features were tested on RAW264.7 murine macrophages. Materials and Methods: LA essential oil was produced through the process of hydro-distillation, and its phytochemical content was determined using the gas chromatography-mass spectrometry (GC-MS) analysis. The antileishmanial effects of LA (0.063 to1 µL/mL) on L. infantum parasites as well as their safety features were assessed on RAW264.7 murine macrophages. Results: The composition of LA essential oil was detected using GC-MS analysis, including linalool, pinene, 1, 8-cineole, linalyl acetate, and lavandulol. Concentrations at and above 0.5 µL/mL LA indicated a significant reduction (71% decrease) in the parasite proliferation, and caused a slight reduction in macrophage viability to 70% at 72 h. Conclusions: The findings revealed the antileishmanial effect of LA on L. infantum parasites with relatively less toxicity on macrophages. The promising antileishmanial efficacy highlights the potential for further in vivo studies.
Açıklama
This study was funded by the Department of Genetics and Bioengineering, Yeditepe University.
Anahtar Kelimeler
Antileishmanial Therapy, Lavandula Angustifolia, Leishmania Infantum, Macrophages
Kaynak
Experimed
WoS Q Değeri
Scopus Q Değeri
Cilt
13
Sayı
2
Künye
İşlek, Z. & Şahin, F. (2023). In vitro antileishmanial activity of Lavandula angustifolia essential oil on leishmania infantum parasites. Experimed, 13(2), pp. 115-120. https://doi.org/10.26650/experimed.1301967
