In vitro antileishmanial activity of Lavandula angustifolia essential oil on leishmania infantum parasites

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dc.authorid0000-0003-4789-9095en_US
dc.authorscopusid57212405586en_US
dc.authorwosidAER-3170-2022en_US
dc.contributor.authorİşlek, Zeynep
dc.contributor.authorŞahin, Fikrettin
dc.date.accessioned2023-09-12T06:17:11Z
dc.date.available2023-09-12T06:17:11Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.descriptionThis study was funded by the Department of Genetics and Bioengineering, Yeditepe University.en_US
dc.description.abstractObjective: Leishmaniasis is an endemic tropical disease that is disseminated through the bite of a sandfly infected with Leishmania parasites. Conventional antileishmanial drugs are mainly toxic and can be ineffective; therefore, there is a need for new natural drug candidates. This study investigated the antileishmanial effects of Lavandula angustifolia (LA) essential oil on Leishmania infantum (L. infantum) parasites, and the safety features were tested on RAW264.7 murine macrophages. Materials and Methods: LA essential oil was produced through the process of hydro-distillation, and its phytochemical content was determined using the gas chromatography-mass spectrometry (GC-MS) analysis. The antileishmanial effects of LA (0.063 to1 µL/mL) on L. infantum parasites as well as their safety features were assessed on RAW264.7 murine macrophages. Results: The composition of LA essential oil was detected using GC-MS analysis, including linalool, pinene, 1, 8-cineole, linalyl acetate, and lavandulol. Concentrations at and above 0.5 µL/mL LA indicated a significant reduction (71% decrease) in the parasite proliferation, and caused a slight reduction in macrophage viability to 70% at 72 h. Conclusions: The findings revealed the antileishmanial effect of LA on L. infantum parasites with relatively less toxicity on macrophages. The promising antileishmanial efficacy highlights the potential for further in vivo studies.en_US
dc.identifier.citationİşlek, Z. & Şahin, F. (2023). In vitro antileishmanial activity of Lavandula angustifolia essential oil on leishmania infantum parasites. Experimed, 13(2), pp. 115-120. https://doi.org/10.26650/experimed.1301967en_US
dc.identifier.doi10.26650/experimed.1301967en_US
dc.identifier.endpage120en_US
dc.identifier.issn2667-5846
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85173918098en_US
dc.identifier.startpage115en_US
dc.identifier.trdizinid1277133
dc.identifier.urihttps://doi.org/10.26650/experimed.1301967
dc.identifier.urihttps://hdl.handle.net/20.500.13055/537
dc.identifier.volume13en_US
dc.identifier.wosWOS:001322146800008
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorİşlek, Zeynep
dc.language.isoenen_US
dc.publisherIstanbul Universityen_US
dc.relation.ispartofExperimeden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntileishmanial Therapyen_US
dc.subjectLavandula Angustifoliaen_US
dc.subjectLeishmania Infantumen_US
dc.subjectMacrophagesen_US
dc.titleIn vitro antileishmanial activity of Lavandula angustifolia essential oil on leishmania infantum parasitesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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