Tailoring natural solvents: Deep eutectic approach for recovering bioactives from Prunus Spinosa L.

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dc.authorid0000-0003-2351-172X
dc.authorid0000-0002-5056-4459
dc.authorid0000-0002-9989-9823
dc.contributor.authorBozkurt, Rabia Nur
dc.contributor.authorFalsafi, Seid Reza
dc.contributor.authorŞahin, Selin
dc.date.accessioned2025-08-26T14:44:37Z
dc.date.available2025-08-26T14:44:37Z
dc.date.issued2025
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümü
dc.description.abstractIn this study, several choline chloride (ChCl)-based deep eutectic solvent (DES) combinations were prepared at different molarratios (1/1, 1/2, and 2/1) using amine (urea), polyols (ethylene glycol and glycerol), and carboxylic acids (lactic acid, formic acid,propionic acid, and acetic acid). The performances of the DESs in the homogeniser-assisted extraction of Prunus spinosa L.fresh fruit were compared depending on the total phenolic content (TPC), total anthocyanin content (TAC), and 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity (antioxidant activity [AA]) yields. Based on the findings of Tukey’s test formultiple comparisons, ChCl/formic acid (2/1) provided the best extraction efficiency with statistically significant differences(p < 0.05). Fourier-transform infrared spectroscopy was used to confirm the formation of the proposed DES. Furthermore, theproposed DES also showed better performance compared to conventional aqueous ethanol (60%, v/v) and water. Then, theselected DES (ChCl/formic acid, 2/1) was employed for the optimization study using the Box-Behnken Design of the responsesurface methodology. The optimum process conditions for the maximum yields of TPC (52.34 mg-GAE/g-FF), TAC (2.09 mg-cyn-3-glu/g-FF), and AA (89.21%) were found to be 50% (v/v) water in the DES, 0.833 g of material, and 69.906 s extractiontime.
dc.identifier.citationBozkurt, R. N., Falsafi, S. R., Şahin, S. (2025). Tailoring natural solvents: Deep eutectic approach for recovering bioactives from Prunus Spinosa L. Chemistry & Biodiversity, pp. 1-14. https://doi.org/10.1002/cbdv.202501858
dc.identifier.doi10.1002/cbdv.202501858
dc.identifier.endpage14
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.pmidPMID: 40839686
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1002/cbdv.202501858
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1087
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorBozkurt, Rabia Nur
dc.institutionauthorid0000-0003-2351-172X
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCholine Chloride-Based Solvents
dc.subjectDesign of Experiments (Doe)
dc.subjectGreen Extraction
dc.subjectNatural Solvent Systems
dc.subjectTukey’s Test
dc.titleTailoring natural solvents: Deep eutectic approach for recovering bioactives from Prunus Spinosa L.
dc.typeArticle
dspace.entity.typePublication

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