Restless legs syndrome in children with celiac disease: Associations with vitamin D and iron deficiency and the role of gluten-free diet adherence

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dc.authorid0000-0002-7095-8121
dc.authorid0000-0002-6055-7746
dc.authorid0000-0002-9914-3321
dc.authorid0000-0002-1720-9711
dc.contributor.authorCebe Tok, Ayşegül
dc.contributor.authorKöle, Mehmet Tolga
dc.contributor.authorGüven, Deniz
dc.contributor.authorTehçi̇, Ali Kansu
dc.contributor.authorKandemi̇r, İbrahim
dc.date.accessioned2026-04-14T13:49:51Z
dc.date.available2026-04-14T13:49:51Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground Celiac disease (CD) is a systemic autoimmune disorder frequently associated with micronutrient deficiencies and extraintestinal manifestations, including neurological complications. Restless Legs Syndrome (RLS) is a sensorimotor disorder linked to dopaminergic dysfunction and iron and vitamin D deficiency, both of which are common in pediatric CD. Objective To evaluate the prevalence and severity of RLS in children with CD and to investigate the associations between RLS symptoms and serum vitamin D and iron parameters, as well as the potential effect of gluten-free diet (GFD) adherence. Methods This prospective cross-sectional study included 67 children with CD (aged 10–18 years) and 68 age- and sex-matched healthy controls. RLS was assessed using the International Restless Legs Syndrome Study Group rating scale. Demographic, anthropometric, clinical, and biochemical data—including serum iron, ferritin, folate, vitamin B12, and 25-hydroxyvitamin D—were recorded. Group comparisons were performed using appropriate parametric or non-parametric tests. Associations were evaluated using Spearman correlation and Bayesian correlation analyses. Results RLS scores were significantly higher in the CD group compared with controls (median 6 [0–13] vs. 0 [0–0]; p < 0.001), and RLS duration was also longer in children with CD (p < 0.001). Serum vitamin D levels showed a significant negative correlation with RLS scores (r = −0.251, p < 0.05). RLS duration demonstrated a strong positive correlation with RLS severity (r = 0.838, p < 0.001). Transglutaminase IgA levels were inversely correlated with ferritin (r = −0.417, p < 0.001) and folate levels (r = −0.332, p < 0.05), while transglutaminase IgG levels were negatively correlated with ferritin (r = −0.285, p < 0.05) and vitamin D (r = −0.304, p < 0.05). Bayesian correlation analysis revealed no strong associations between Marsh classification and most clinical or biochemical variables, except for a strong association between RLS duration and severity (BF₁₀ > 100). Adherence to a gluten-free diet was not significantly associated with RLS severity (p > 0.05). Conclusions Children with celiac disease exhibit significantly higher RLS symptom severity than healthy peers. Lower serum vitamin D levels and reduced iron stores appear to be associated with increased RLS severity, regardless of Marsh stage or dietary adherence. These findings highlight the potential value of screening for RLS and monitoring vitamin D and ferritin levels in pediatric patients with celiac disease.
dc.identifier.citationCebe Tok, A., Köle, M. T., Güven, D., Tehçi̇, A. K., & Kandemi̇r, İ. (2026). Restless legs syndrome in children with celiac disease: Associations with vitamin D and iron deficiency and the role of gluten-free diet adherence. BMC Pediatrics, https://doi.org/10.1186/s12887-026-06720-x
dc.identifier.doi10.1186/s12887-026-06720-x
dc.identifier.issn1471-2431
dc.identifier.pmidPMID: 41851650
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s12887-026-06720-x
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1408
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorKandemi̇r, İbrahim
dc.institutionauthorid0000-0002-1720-9711
dc.language.isoen
dc.publisherBioMed Central
dc.relation.ispartofBMC Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCeliac Disease
dc.subjectChildren
dc.subjectRestless Legs Syndrome (RLS)
dc.subjectIron Deficiency
dc.subjectVitamin D Deficiency
dc.titleRestless legs syndrome in children with celiac disease: Associations with vitamin D and iron deficiency and the role of gluten-free diet adherence
dc.typeArticle
dspace.entity.typePublication

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