Safety monitoring of colistin therapy in critically ıll neonates with late-onset sepsis: A retrospective observational study

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dc.authorid0000-0002-4834-9127
dc.authorid0000-0002-7550-6765
dc.authorid0000-0003-0070-6292
dc.authorid0000-0003-1694-8720
dc.authorid0000-0002-1720-9711
dc.authorid0000-0003-2579-9480
dc.authorid0000-0002-5698-8930
dc.contributor.authorAcargök, Baran Cengiz
dc.contributor.authorYaman, Akan
dc.contributor.authorRzayev, Turkay
dc.contributor.authorJalalzada, Nazlı
dc.contributor.authorKandemir, İbrahim
dc.contributor.authorMemişoğlu, Aslı
dc.contributor.authorBilgen, Hülya Selva
dc.date.accessioned2025-10-14T13:03:18Z
dc.date.available2025-10-14T13:03:18Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractThis study aimed to evaluate the safety of colistin therapy by monitoring renal function and electrolyte levels in critically ill neonates with late-onset sepsis (LOS) hospitalized in the neonatal intensive care unit (NICU) between 2015 and 2021. This ret rospective case–control study included 58 critically ill neonates treated with colistin for late-onset sepsis and 22 control neonates with late-onset sepsis who did not receive colistin. Data were analyzed to compare patient outcomes, microbiological profiles, and side effects of treatment. Statistical analyses were performed using repeated-measures ANOVA and Bayesian calculations to evaluate serum creatinine levels and biochemical parameters over time. Serum creatinine levels showed similar alterations within the first 7days of colistin treatment with moderate evidence. However, serum magnesium and sodium levels were lower on the 7th day in the colistin-treated group compared with the control group. Colistin therapy in critically ill neonates with late-onset sepsis appears to be a viable treatment option with an acceptable short-term safety profile. These findings emphasize the importance of routine monitoring of renal function and electrolyte levels during colistin use in neonatal intensive care to minimize potential complications.
dc.identifier.citationAcargök, B. C., Yaman, A., Rzayev, T., Jalalzada, N., Kandemir, İ., Memişoğlu, A., & Bilgen, H. S. (2025). Safety monitoring of colistin therapy in critically ıll neonates with late-onset sepsis: A retrospective observational study. Pharmacology Research & Perspectives, 13(5), pp. 1-7. https://doi.org/10.1002/prp2.70178
dc.identifier.doi10.1002/prp2.70178
dc.identifier.endpage7
dc.identifier.issn2052-1707
dc.identifier.issue5
dc.identifier.pmidPMID: 41028664
dc.identifier.scopus2-s2.0-105017611667
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1002/prp2.70178
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1135
dc.identifier.volume13
dc.identifier.wosWOS:001586128300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorKandemir, İbrahim
dc.institutionauthorid0000-0002-1720-9711
dc.language.isoen
dc.publisherBritish Pharmacological Society
dc.relation.ispartofPharmacology Research & Perspectives
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectColistin
dc.subjectHypomagnesemia
dc.subjectLate-Onset Sepsis
dc.subjectMultidrug-Resistant Microorganisms
dc.subjectNeonatal İntensive Care Unit
dc.subjectNeonate
dc.titleSafety monitoring of colistin therapy in critically ıll neonates with late-onset sepsis: A retrospective observational study
dc.typeArticle
dspace.entity.typePublication

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