Gender differences in the distribution of IDL, LDL, and HDL lipoprotein subfractions in MODY compared to type 2 diabetes: Data from the MODY-Ist study

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dc.authorid0000-0002-8837-6664
dc.authorid0000-0003-2728-7323
dc.authorid0000-0002-1187-944X
dc.authorid0000-0003-1399-3382
dc.authorid0000-0001-6806-9678
dc.authorid0000-0002-8119-2862
dc.authorid0000-0001-8924-4850
dc.authorid0000-0002-7350-6032
dc.authorid0000-0002-2439-9269
dc.authorid0000-0001-8613-1797
dc.contributor.authorYılmaz Aydoğan, Hülya
dc.contributor.authorKanca Demirci, Deniz
dc.contributor.authorGül, Nurdan
dc.contributor.authorYanar, Fatih
dc.contributor.authorPoyrazoğlu, Şükran
dc.contributor.authorGüleç Yılmaz, Seda
dc.contributor.authorTüzüner, Mete Bora
dc.contributor.authorİsbir, Turgay
dc.contributor.authorÖztürk, Oğuz
dc.contributor.authorSatman, İlhan
dc.date.accessioned2025-12-05T13:31:45Z
dc.date.available2025-12-05T13:31:45Z
dc.date.issued2025
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalı
dc.description.abstractBackground: The distribution of intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL) and high density lipoprotein (HDL) subfractions specific to diabetes types and changes under dyslipidemia conditions have been well characterised. Research into the distribution of lipoprotein subfractions in Maturity-Onset Diabetes of the Young (MODY) has hitherto been confined to certain subtypes, with gender-based differences remaining to be elucidated. The objective of this study was to comparatively evaluate the distribution of lipoprotein subfractions according to gender in MODY, T2DM patients, and control groups. Methods: Lipoprotein subfractions in 119 serum samples of the study groups were analyzed using the Lipoprint System. Results: The midbands of IDL (MID-A to C) in female MODY cases, and the HDL-small fraction in male MODY cases, were found to be lower compared to female and male T2DM cases, respectively. In the T2DM group, age was positively correlated with MID-C and MID-B in both genders, while it was negatively correlated with MID-A in female cases. ROC analysis demonstrated that the decrease in the MID-C fraction in female MODY subjects (AUC:0.809, p = 0.0001) and the decrease in the HDL-small fraction in male MODY subjects (AUC:0.818, p = 0.002) were significantly associated with the likelihood of MODY. Conclusion: Given that a considerable proportion of MODY patients are frequently misdiagnosed as T2DM, low levels of MID-C and HDL-small fractions, both of which are triglyceride-rich, may have potential as a diagnostic value for female and male MODY patients, respectively.
dc.description.sponsorshipThis study was funded by Istanbul University Scientific Research Project Unit (Project no. TOA-2017-24194). Bu çalışma İstanbul Üniversitesi Bilimsel Araştırma Projeleri Birimi (Proje no. TOA-2017-24194) tarafından finanse edilmiştir.
dc.identifier.citationYılmaz Aydoğan, H., Kanca Demirci, D., Gül, N., Yanar, F., Poyrazoğlu, Ş., Güleç Yılmaz, S., Tüzüner, M. B., İsbir, T., Öztürk, O., & Satman, İ. (2025). Gender differences in the distribution of IDL, LDL, and HDL lipoprotein subfractions in MODY compared to type 2 diabetes: Data from the MODY-Ist study. Journal of Diabetes and Its Complications, 39(12), pp. 1-9. https://doi.org/10.1016/j.jdiacomp.2025.109196
dc.identifier.doi10.1016/j.jdiacomp.2025.109196
dc.identifier.endpage9
dc.identifier.issn1873-460X
dc.identifier.issn1056-8727
dc.identifier.issue12
dc.identifier.pmidPMID: 41236011
dc.identifier.scopus2-s2.0-105020973709
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.jdiacomp.2025.109196
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1210
dc.identifier.volume39
dc.identifier.wosWOS:001608020600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorTüzüner, Mete Bora
dc.institutionauthorid0000-0001-8924-4850
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Diabetes and Its Complications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMODY
dc.subjectT2DM
dc.subjectIDL
dc.subjectLDL
dc.subjectHDL
dc.subjectLipoprotein Subfractions
dc.titleGender differences in the distribution of IDL, LDL, and HDL lipoprotein subfractions in MODY compared to type 2 diabetes: Data from the MODY-Ist study
dc.typeArticle
dspace.entity.typePublication

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