Long-term outcomes of extended versus segmental resection for transverse colon cancer: A population-based analysis based on the SEER database

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dc.authorid0000-0002-5211-1779
dc.authorid0000-0002-4707-6059
dc.authorid0000-0002-5317-8545
dc.authorid0000-0002-9620-5080
dc.authorid0000-0001-7725-3522
dc.authorid0000-0002-5703-4549
dc.authorid0000-0003-1704-2533
dc.contributor.authorBenlice, Çiğdem
dc.contributor.authorErkaya, Metincan
dc.contributor.authorAghayeva, Afag
dc.contributor.authorÖzben, Volkan
dc.contributor.authorGörgün, Emre
dc.contributor.authorAtasoy, Deniz
dc.contributor.authorBaca, Bilgi
dc.date.accessioned2025-10-19T09:35:41Z
dc.date.available2025-10-19T09:35:41Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractObjective: To investigate long-term cancer-specific outcomes associated with extended versus segmental colectomy (SC) in patients with stage I-III transverse colon adenocarcinoma using a large, population-based cohort. Material and Methods: Patients who diagnosed with transverse colon cancer undergoing curative-intent colectomy were identified from the surveillance, epidemiology, and end results database (2013-2019). Surgical procedures were categorized as extended colectomy (EC) or SC based on standardized procedural coding. 1:1 propensity score matching was performed to reduce selection bias and balance baseline characteristics. Cancer-specific survival (CSS) was analyzed using multivariable Cox proportional hazards regression. Results: Among 18,799 eligible patients, 58% underwent EC. EC was more frequently performed in individuals with higher tumor stage (p<0.01) and those receiving adjuvant chemotherapy (26% vs. 23%, p<0.01). After matching (n=7.904 in each group), EC was associated with a higher rate of adequate lymphadenectomy (>12 lymph nodes retrieved: 94% vs. 89%, p<0.01). Five-year overall survival did not differ significantly between groups (65.6% for EC vs. 66.9% for SC, p=0.074). However, SC was associated with a modest but statistically significant improvement in CSS (84.3% vs. 81.7%, p<0.01). In adjusted analysis, surgical extent (HR=0.8376, p<0.001), along with age, sex, tumor grade, stage, and lymph node yield, were independently associated with CSS. Conclusion: While EC is more commonly utilized in advanced-stage disease and facilitates higher lymph node retrieval, SC offers comparable—and potentially superior—CSS in selected patients. These findings support the consideration of a tailored surgical strategy based on tumor biology and individual patient characteristics.
dc.identifier.citationBenlice, Ç., Erkaya, M., Aghayeva, A., Özben, V., Görgün, E., Atasoy, D., & Baca, B. (2025). Long-term outcomes of extended versus segmental resection for transverse colon cancer: A population-based analysis based on the SEER database. Turkish Journal of Surgery, https://doi.org/10.47717/turkjsurg.2025.2025-7-6
dc.identifier.doi10.47717/turkjsurg.2025.2025-7-6
dc.identifier.issn2564-7032
dc.identifier.issn2564-6850
dc.identifier.pmidPMID: 41059610
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.47717/turkjsurg.2025.2025-7-6
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1138
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Index
dc.institutionauthorBenlice, Çiğdem
dc.institutionauthorAtasoy, Deniz
dc.institutionauthorid0000-0002-5211-1779
dc.institutionauthorid0000-0002-5703-4549
dc.language.isoen
dc.publisherGalenos Publishing House
dc.relation.ispartofTurkish Journal of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTransverse Colon
dc.subjectSegmental Colectomy
dc.subjectExtended Colectomy
dc.subjectSEER
dc.subjectSurvival
dc.titleLong-term outcomes of extended versus segmental resection for transverse colon cancer: A population-based analysis based on the SEER database
dc.typeArticle
dspace.entity.typePublication

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