Investigating leptin gene variants and methylation status in relation to breastfeeding and preventing obesity

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dc.authorid0000-0003-1272-5845
dc.authorid0000-0002-2564-8298
dc.authorid0000-0001-6787-2565
dc.authorid0000-0002-1720-9711
dc.authorid0000-0003-0697-4271
dc.authorid0000-0001-6806-9678
dc.authorid0000-0003-0594-8741
dc.authorid0000-0003-3570-8394
dc.contributor.authorKılıç, Ayşe
dc.contributor.authorPehlivan, Sacide
dc.contributor.authorVarkal, Mehmet Ali
dc.contributor.authorTuncel, Fatima Ceren
dc.contributor.authorKandemir, İbrahim
dc.contributor.authorÖzçetin, Mustafa
dc.contributor.authorPoyrazoğlu, Şükran
dc.contributor.authorKardelen, Aslı Derya
dc.contributor.authorÖzdemir, İrem
dc.contributor.authorYıldız, İsmail
dc.date.accessioned2024-10-31T10:06:03Z
dc.date.available2024-10-31T10:06:03Z
dc.date.issued2024
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: We investigated whether the results of leptin gene (LEP) 2548G/A (rs7799039) and leptin receptor gene (LEPR) 668 A/G (rs1137101) variants, as well as the methylation analysis of CpG regions at nucleotides −31 and −51 of the LEP gene, showed any differences between breastfed and non-breastfed children in this study. Materials and Methods: The cross-sectional study included 100 children aged 2–5 years who were attending nursery and kindergarten and had been accepted to the Department of General Paediatrics. Infants who were exclusively breastfed for the first six months after birth constituted the study group, and those who were not only breastfeed constituted the control group. Methylation percentages at CpG islands of the LEP gene were compared between exclusively breastfed and non-exclusively breastfed infants, and the statistical significance was analyzed by looking for changes in LEP −31 and −51 nt methylation and LEP 2548G/A ve LEPR 668 A/G variants. Results: Both groups were compared by feeding, and the association of LEPR and LEP gene polymorphisms and −51 nt and −31 nt methylations were analyzed. There were no significant differences between the groups regarding genotype and allele frequency for the LEPR 668 A/G, LEP 2548 G/A gene variant, −31 nt methylation, and −51 nt methylation status. Similarly, there was no significant difference in genotype and allele frequency for the LEPR 668 A/G gene variant in terms of duration of exclusive breastfeeding, total breastfeeding, body mass index, family obesity, and satiety status. However, maternal support from family elders and physical activity increased the 51 nt methylation, but this methylation was not significantly affected by BMI, age, or satiety status. Conclusions: Maternal support from family elders and physical activity were associated with increased 51 nt methylation, but this methylation was not significantly affected by BMI, age, or satiety status. However, there are not enough studies in this area to reach a definitive conclusion, and further research is needed.
dc.identifier.citationKılıç, A., Pehlivan, S., Varkal, M. A., Tuncel, F. C., Kandemir , I., Özçetin, M., Poyrazoğlu, S., Kardelen, A. D. , Özdemir, I. , & Yıldız, I. (2024) Investigating leptin gene variants and methylation status in relation to breastfeeding and preventing obesity. Children, 11(11), pp. 1-12. https://doi.org/10.3390/children11111293
dc.identifier.doi10.3390/children11111293
dc.identifier.endpage12
dc.identifier.issn2227-9067
dc.identifier.issue11
dc.identifier.pmidPMID: 39594868
dc.identifier.scopus2-s2.0-85210557935
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/children11111293
dc.identifier.urihttps://hdl.handle.net/20.500.13055/840
dc.identifier.volume11
dc.identifier.wosWOS:001364121000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorKandemir, İbrahim
dc.institutionauthorid0000-0002-1720-9711
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofChildren
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreast Milk
dc.subjectLeptin
dc.subjectEpigenetics
dc.subjectObesity
dc.titleInvestigating leptin gene variants and methylation status in relation to breastfeeding and preventing obesity
dc.typeArticle
dspace.entity.typePublication

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