Effect of biphenyl derivative of coumarin compounds photodynamic therapy on the expression of carcinoma-associated genes

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Küçük Resim

Tarih

2024

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Slovensko Kemijsko Drustvo

Erişim Hakkı

info:eu-repo/semantics/openAccess

Araştırma projeleri

Organizasyon Birimleri

Dergi sayısı

Özet

Photodynamic Therapy (PDT) is a cancer treatment. Singlet oxygen is produced as a result of the photochemical reaction between light, photosensitizer (PS), and molecular oxygen, which kills cells. Colon cancer, affecting 1.23 million people worldwide, often requires surgery but has high recurrence and metastasis rates. Photodynamic therapy (PDT) repre-sents an alternative treatment for colon cancer. This study used MTT assays to evaluate cell viability and applied Zinc (II) Phthalocyanine (ZnPc) photosensitizers to the colorectal adenocarcinoma (HT-29) cell line to investigate cancer pathways via flow cytometry and q-PCR. The results showed that PDT with ZnPc significantly reduced cell viability in HT-29 cells and induced apoptosis at a rate of 53%. According to q-PCR results, CT values of ten out of thirty genes were significant, and their association with cancer was evaluated.

Açıklama

Anahtar Kelimeler

Photodynamic Therapy, HT-29 Cancer Cell, Coumarin, Phthalocyanine, Gene Expression

Kaynak

Acta Chimica Slovenica

WoS Q Değeri

Q3

Scopus Q Değeri

Q3

Cilt

71

Sayı

4

Künye

Gök Yurttaş, A., Elgün, T., Erkal Çam, B., Kefeli, M., & Çınar, K. (2024). Effect of biphenyl derivative of coumarin compounds photodynamic therapy on the expression of carcinoma-associated genes. Acta Chimica Slovenica, 71(4), pp. 696-704. https://doi.org/10.17344/acsi.2024.8948