Effect of biphenyl derivative of coumarin compounds photodynamic therapy on the expression of carcinoma-associated genes

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dc.authorid0000-0002-6424-7411
dc.authorid0000-0002-1311-6892
dc.authorid0000-0002-0275-5613
dc.authorid0000-0002-1192-6947
dc.contributor.authorGök Yurttaş, Asiye
dc.contributor.authorElgün, Tuğba
dc.contributor.authorErkal Çam, Burçin
dc.contributor.authorKefeli, Melike
dc.contributor.authorÇınar, Kamil
dc.date.accessioned2025-01-03T13:25:08Z
dc.date.available2025-01-03T13:25:08Z
dc.date.issued2024
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalı
dc.description.abstractPhotodynamic Therapy (PDT) is a cancer treatment. Singlet oxygen is produced as a result of the photochemical reaction between light, photosensitizer (PS), and molecular oxygen, which kills cells. Colon cancer, affecting 1.23 million people worldwide, often requires surgery but has high recurrence and metastasis rates. Photodynamic therapy (PDT) repre-sents an alternative treatment for colon cancer. This study used MTT assays to evaluate cell viability and applied Zinc (II) Phthalocyanine (ZnPc) photosensitizers to the colorectal adenocarcinoma (HT-29) cell line to investigate cancer pathways via flow cytometry and q-PCR. The results showed that PDT with ZnPc significantly reduced cell viability in HT-29 cells and induced apoptosis at a rate of 53%. According to q-PCR results, CT values of ten out of thirty genes were significant, and their association with cancer was evaluated.
dc.identifier.citationGök Yurttaş, A., Elgün, T., Erkal Çam, B., Kefeli, M., & Çınar, K. (2024). Effect of biphenyl derivative of coumarin compounds photodynamic therapy on the expression of carcinoma-associated genes. Acta Chimica Slovenica, 71(4), pp. 696-704. https://doi.org/10.17344/acsi.2024.8948
dc.identifier.doi10.17344/acsi.2024.8948
dc.identifier.endpage704
dc.identifier.issn1580-3155
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85213878978
dc.identifier.scopusqualityQ3
dc.identifier.startpage696
dc.identifier.urihttps://hdl.handle.net/20.500.13055/886
dc.identifier.urihttps://doi.org/10.17344/acsi.2024.8948
dc.identifier.volume71
dc.identifier.wosWOS:001381504700015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGök Yurttaş, Asiye
dc.institutionauthorid0000-0002-6424-7411
dc.language.isoen
dc.publisherSlovensko Kemijsko Drustvo
dc.relation.ispartofActa Chimica Slovenica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPhotodynamic Therapy
dc.subjectHT-29 Cancer Cell
dc.subjectCoumarin
dc.subjectPhthalocyanine
dc.subjectGene Expression
dc.titleEffect of biphenyl derivative of coumarin compounds photodynamic therapy on the expression of carcinoma-associated genes
dc.typeArticle
dspace.entity.typePublication

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