The protective role of vitamins C and E in steroid-induced femoral head osteonecrosis: An experimental study in rats

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dc.authorid0000-0002-6424-7411en_US
dc.authorscopusid57366670900en_US
dc.authorwosidCJT-9277-2022en_US
dc.contributor.authorBeytemur, Ozan
dc.contributor.authorDaşçı, Mustafa Fatih
dc.contributor.authorGök Yurttaş, Asiye
dc.contributor.authorYaprak Bayrak, Büşra
dc.contributor.authorAlagöz, Ender
dc.date.accessioned2023-11-27T08:43:13Z
dc.date.available2023-11-27T08:43:13Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalıen_US
dc.description.abstractObjectives: This study aimed to determine whether vitamin C (VC) and vitamin E (VE) can effectively protect the femoral head and reduce the risk of developing osteonecrosis in rats that have been treated with steroids.Materials and methods: The study was conducted on 30 young adult male Sprague-Dawley rats (mean weight: 356 +/- 18 g; range, 330 to 375 g), which were randomly assigned to one of five groups. The control group received saline solution, while the other groups were given lipopolysaccharide/methylprednisolone (LPS/MPS) to induce osteonecrosis. Three groups in which osteonecrosis was induced were also intraperitoneally administered either VC, VE, or both once a day for four weeks. Intracardiac blood samples were taken at the end of the fourth week for biochemical examination, and the rats were then sacrificed under general anesthesia. After sacrification, right femurs were removed for histopathological, immunohistochemical, and radiologic examinations.Results: The results showed that the mean trabecular number increased significantly in the VC+VE group. There was a substantial decrease observed in the mean trabecular separation within the LPS/MPS group compared to the control group, although trabecular separation decreased in all three vitamin groups compared to the LPS/MPS group. The surface area/bone volume was significantly increased in the VC+VE group compared to the LPS/MPS group. Histological, immunohistochemical, and radiological examinations showed that the administration of VC and VE significantly reduced oxidative stress, inflammation, and microvascular dysfunction in rats with steroid-induced femoral head osteonecrosis.Conclusion: This study suggests that VC, VE, and particularly VC+VE have a protective effect on the femoral head in rats with steroid-induced femoral head osteonecrosis. These findings may lead to new treatment options for patients.en_US
dc.identifier.citationBeytemur, O., Daşçı, M. F., Gök Yurttaş, A., Yaprak Bayrak, B., & Alagöz, E. (2024). The protective role of vitamins C and E in steroid-induced femoral head osteonecrosis: An experimental study in rats. Joint Diseases and Related Surgery, 35(1), pp. 72-84. https://doi.org/10.52312/jdrs.2023.1405en_US
dc.identifier.doi10.52312/jdrs.2023.1405en_US
dc.identifier.endpage84en_US
dc.identifier.issue1en_US
dc.identifier.pmidPMID: 38108168en_US
dc.identifier.scopus2-s2.0-85180384278en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage72en_US
dc.identifier.trdizinid1227228
dc.identifier.urihttps://hdl.handle.net/20.500.13055/587
dc.identifier.urihttps://doi.org/10.52312/jdrs.2023.1405
dc.identifier.volume35en_US
dc.identifier.wosWOS:001096926100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorGök Yurttaş, Asiye
dc.language.isoenen_US
dc.publisherTurkish Joint Diseases Foundationen_US
dc.relation.ispartofJoint Diseases and Related Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLipopolysaccharideen_US
dc.subjectMethylprednisoloneen_US
dc.subjectOsteonecrosis of Femoral Headen_US
dc.subjectVitamin Cen_US
dc.subjectVitamin Een_US
dc.titleThe protective role of vitamins C and E in steroid-induced femoral head osteonecrosis: An experimental study in ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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