Managing CDH1 cancer risks in a child: Complex decision making in a family with hereditary diffuse gastric cancer
Yükleniyor...
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Germline pathogenic variants (PVs) in CDH1 cause hereditary diffuse gastric cancer. The management of CDH1 cases with a positive family history includes total prophylactic gastrectomy or intensive surveillance. In this study, we report a 16-year-old boy with intramucosal gastric signet ring cells in the setting of a germline CDH1 PV and a family history of early-onset gastric cancer. The approach to managing both the proband and their 9-year-old sister, who also had the CDH1 PV, presented a challenge to both clinicians and the family. Herein, we present the complexities of managing gastric cancer risk when a CDH1 PV is identified in childhood in the setting of a family history of early-onset gastric cancer.
Açıklama
Anahtar Kelimeler
CDH1, Adolescent, Diffuse Gastric Cancer, Pediatric, Young Adult
Kaynak
American Journal of Medical Genetics Part A
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
197
Sayı
2
Künye
Ağaoğlu, N. B., Hatırnaz Ng, Ö., Zemheri, İ. E., Ünal, B., Gerenli, N., Tosun, İ., Yazıcı, H., Özbek, U., Kamihara, J., & Rana, H. Q. (2025). Managing CDH1 cancer risks in a child: Complex decision making in a family with hereditary diffuse gastric cancer. American Journal of Medical Genetics Part A, 197(2), pp. 1-5. https://doi.org/10.1002/ajmg.a.63897
