Managing CDH1 cancer risks in a child: Complex decision making in a family with hereditary diffuse gastric cancer
dc.contributor.author | Ağaoğlu, Nihat Buğra | |
dc.contributor.author | Hatırnaz Ng, Özden | |
dc.contributor.author | Zemheri, İtir Ebru | |
dc.contributor.author | Ünal, Büşra | |
dc.contributor.author | Gerenli, Nelgin | |
dc.contributor.author | Tosun, İlkay | |
dc.contributor.author | Yazıcı, Hülya | |
dc.contributor.author | Özbek, Uğur | |
dc.contributor.author | Kamihara, Junne | |
dc.contributor.author | Rana, Huma Q. | |
dc.date.accessioned | 2024-10-16T14:16:59Z | |
dc.date.available | 2024-10-16T14:16:59Z | |
dc.date.issued | 2024 | |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı | |
dc.description.abstract | Germline pathogenic variants (PVs) in CDH1 cause hereditary diffuse gastric cancer. The management of CDH1 cases with a positive family history includes total prophylactic gastrectomy or intensive surveillance. In this study, we report a 16-year-old boy with intramucosal gastric signet ring cells in the setting of a germline CDH1 PV and a family history of early-onset gastric cancer. The approach to managing both the proband and their 9-year-old sister, who also had the CDH1 PV, presented a challenge to both clinicians and the family. Herein, we present the complexities of managing gastric cancer risk when a CDH1 PV is identified in childhood in the setting of a family history of early-onset gastric cancer. | |
dc.identifier.citation | Ağaoğlu, N. B., Hatırnaz Ng, Ö., Zemheri, İ. E., Ünal, B., Gerenli, N., Tosun, İ., Yazıcı, H., Özbek, U., Kamihara, J., Rana, H. Q. (2024). Managing CDH1 cancer risks in a child: Complex decision making in a family with hereditary diffuse gastric cancer. American Journal of Medical Genetics Part A. https://doi.org/10.1002/ajmg.a.63897 | |
dc.identifier.doi | 10.1002/ajmg.a.63897 | |
dc.identifier.issn | 1552-4833 | |
dc.identifier.issn | 1552-4825 | |
dc.identifier.pmid | PMID: 39392178 | |
dc.identifier.scopus | 2-s2.0-85205985224 | |
dc.identifier.scopusquality | Q3 | |
dc.identifier.uri | https://hdl.handle.net/20.500.13055/821 | |
dc.identifier.uri | https://doi.org/10.1002/ajmg.a.63897 | |
dc.identifier.wos | WOS:001336980900001 | |
dc.identifier.wosquality | Q3 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.indekslendigikaynak.other | SCI-E - Science Citation Index Expanded | |
dc.institutionauthor | Yazıcı, Hülya | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.relation.ispartof | American Journal of Medical Genetics Part A | |
dc.relation.publicationcategory | Diğer | |
dc.relation.tubitak | 1059B192100905 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | CDH1 | |
dc.subject | Adolescent | |
dc.subject | Diffuse Gastric Cancer | |
dc.subject | Pediatric | |
dc.subject | Young Adult | |
dc.title | Managing CDH1 cancer risks in a child: Complex decision making in a family with hereditary diffuse gastric cancer | |
dc.type | Case Report | |
dspace.entity.type | Publication |