Managing CDH1 cancer risks in a child: Complex decision making in a family with hereditary diffuse gastric cancer

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dc.contributor.authorAğaoğlu, Nihat Buğra
dc.contributor.authorHatırnaz Ng, Özden
dc.contributor.authorZemheri, İtir Ebru
dc.contributor.authorÜnal, Büşra
dc.contributor.authorGerenli, Nelgin
dc.contributor.authorTosun, İlkay
dc.contributor.authorYazıcı, Hülya
dc.contributor.authorÖzbek, Uğur
dc.contributor.authorKamihara, Junne
dc.contributor.authorRana, Huma Q.
dc.date.accessioned2024-10-16T14:16:59Z
dc.date.available2024-10-16T14:16:59Z
dc.date.issued2024
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik ve Biyoloji Ana Bilim Dalı
dc.description.abstractGermline pathogenic variants (PVs) in CDH1 cause hereditary diffuse gastric cancer. The management of CDH1 cases with a positive family history includes total prophylactic gastrectomy or intensive surveillance. In this study, we report a 16-year-old boy with intramucosal gastric signet ring cells in the setting of a germline CDH1 PV and a family history of early-onset gastric cancer. The approach to managing both the proband and their 9-year-old sister, who also had the CDH1 PV, presented a challenge to both clinicians and the family. Herein, we present the complexities of managing gastric cancer risk when a CDH1 PV is identified in childhood in the setting of a family history of early-onset gastric cancer.
dc.identifier.citationAğaoğlu, N. B., Hatırnaz Ng, Ö., Zemheri, İ. E., Ünal, B., Gerenli, N., Tosun, İ., Yazıcı, H., Özbek, U., Kamihara, J., Rana, H. Q. (2024). Managing CDH1 cancer risks in a child: Complex decision making in a family with hereditary diffuse gastric cancer. American Journal of Medical Genetics Part A. https://doi.org/10.1002/ajmg.a.63897
dc.identifier.doi10.1002/ajmg.a.63897
dc.identifier.issn1552-4833
dc.identifier.issn1552-4825
dc.identifier.pmidPMID: 39392178
dc.identifier.scopus2-s2.0-85205985224
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://hdl.handle.net/20.500.13055/821
dc.identifier.urihttps://doi.org/10.1002/ajmg.a.63897
dc.identifier.wosWOS:001336980900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorYazıcı, Hülya
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAmerican Journal of Medical Genetics Part A
dc.relation.publicationcategoryDiğer
dc.relation.tubitak1059B192100905
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCDH1
dc.subjectAdolescent
dc.subjectDiffuse Gastric Cancer
dc.subjectPediatric
dc.subjectYoung Adult
dc.titleManaging CDH1 cancer risks in a child: Complex decision making in a family with hereditary diffuse gastric cancer
dc.typeCase Report
dspace.entity.typePublication

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