The therapeutic effects of bioactive compounds on colorectal cancer via PI3K/Akt/mTOR signaling pathway: A critical review

Basit Öğe Kaydı
dc.authorid0000-0002-3644-5066
dc.contributor.authorDemir, Kübra
dc.contributor.authorTurgut, Rana
dc.contributor.authorŞentürk, Selcen
dc.contributor.authorIşıklar, Handan
dc.contributor.authorGünalan, Elif
dc.date.accessioned2024-10-23T06:49:37Z
dc.date.available2024-10-23T06:49:37Z
dc.date.issued2024
dc.departmentEnstitüler, Lisansüstü Eğitim Enstitüsü, Beslenme ve Diyetetik Programı
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractUnderstanding the molecular signaling pathways of colorectal cancer (CRC) can be accepted as the first step in treatment strategy. Permanent mTOR signaling activation stimulates the CRC process via various biological processes. It supplies the survival of CRC stem cells, tumorigenesis, morbidity, and decreased response to drugs in CRC pathogenesis. Therefore, inhibition of the mTOR signaling by numerous bioactive components may be effective against CRC. The study aims to discuss the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. The potential molecular effects of bioactive compounds on the mTOR pathway's upstream and downstream targets are examined. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration, and suppression of glycolysis through mTOR signaling inhibition. As a result, carcinogenesis is inhibited by inducing apoptosis and autophagy. However, it should be noted that studies are primarily in vitro dose-dependent treatment researchers. This study raises awareness about the role of phenolic compounds in treating CRC, contributing to their future use as anticancer agents. These bioactive compounds have the potential to be developed into food supplementation to prevent and treat various cancer types including CRC. This review has the potential to lead to further development of clinical studies. In the future, mTOR inhibition by applying several bioactive agents using advanced drug delivery systems may contribute to CRC treatment with 3D cell culture and in vivo clinical studies.
dc.description.sponsorshipThis article has funded in the scope of TUBITAK-ULAKBIM “Read and Publish” agreement.
dc.identifier.citationDemir, K., Turgut, R., Şentürk, S., Işıklar, H., & Günalan, E. (2024). The therapeutic effects of bioactive compounds on colorectal cancer via PI3K/Akt/mTOR signaling pathway: A critical review. Food Science & Nutrition, pp. 1-23. https://doi.org/10.1002/fsn3.4534
dc.identifier.doi10.1002/fsn3.4534
dc.identifier.endpage23
dc.identifier.issn2048-7177
dc.identifier.scopus2-s2.0-85208238783
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1002/fsn3.4534
dc.identifier.urihttps://hdl.handle.net/20.500.13055/833
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorDemir, Kübra
dc.institutionauthorTurgut, Rana
dc.institutionauthorŞentürk, Selcen
dc.institutionauthorGünalan, Elif
dc.institutionauthorid0000-0002-3644-5066
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofFood Science & Nutrition
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlkaloids
dc.subjectColorectal Cancer
dc.subjectPolyphenols
dc.subjectTerpenoids
dc.titleThe therapeutic effects of bioactive compounds on colorectal cancer via PI3K/Akt/mTOR signaling pathway: A critical review
dc.typeReview Article
dspace.entity.typePublication

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