Preparation and characterization studies of dorzolamide loaded ophthalmic implants for the treatment of glaucoma
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Pharmacists Association
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: This study aimed to construct dorzolamide loaded ophthalmic implants for extended drug delivery and increased drug retention. Materials and Methods: Carboxymethyl cellulose and Chitosan were used to formulate the ophthalmic implants. The implants were prepared by solvent casting technique in existence of polyethylene glycol 6000 as plasticizer. Physiochemical characterization studies including mechanical characteristics (tensile strength, elongation at break, and Young’s modulus), bioadhesion studies, in vitro and ex vivo drug release studies were conducted. Results: Tensile strength of drug loaded ophthalmic implants were 10.70 and 11.68 MPa respectively. Elongation at break of Carboxymethyl cellulose and Chitosan implants were 62.00% and 59.05% respectively. The in vitro release profiles fit into the Higuchi type kinetic model. Ex vivo release study results for both implants were correlated with in vitro release investigations. Conclusion: Carboxymethyl cellulose and Chitosan based implants provide extended drug delivery. Implants were prepared by using carboxymethyl cellulose provide significantly slower in vitro release rate, and the drug retention on ocular surfaces has been increased. Thus, it has been concluded that, dorzolamide loaded carboxymethyl cellulose implants could provide effective treatment for glaucoma
Açıklama
Anahtar Kelimeler
Dorzolamide, Carboxymethyl Cellulose, Chitosan, Ocular Implant
Kaynak
The Turkish Journal of Pharmaceutical Sciences
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
20
Sayı
3
Künye
Özdemir, S., Çakırlı, E., Bilge S., Aygüler, C. İ., Üner, B. & Çelebi, A. R. C. (2023). Preparation and characterization studies of dorzolamide loaded ophthalmic implants for the treatment of glaucoma. The Turkish Journal of Pharmaceutical Sciences, 20(3), pp. 149-156. https://doi.org/10.4274/tjps.galenos.2022.95752
