Preparation and characterization studies of dorzolamide loaded ophthalmic implants for the treatment of glaucoma

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dc.authorid0000-0001-6212-2706en_US
dc.authorscopusid57194855634en_US
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorÇakırlı, Egemen
dc.contributor.authorSürücü, Bilge
dc.contributor.authorAygüler, Cemre İrem
dc.contributor.authorÜner, Burcu
dc.contributor.authorÇelebi, Ali Rıza Cenk
dc.date.accessioned2022-12-31T09:12:08Z
dc.date.available2022-12-31T09:12:08Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractObjectives: This study aimed to construct dorzolamide loaded ophthalmic implants for extended drug delivery and increased drug retention. Materials and Methods: Carboxymethyl cellulose and Chitosan were used to formulate the ophthalmic implants. The implants were prepared by solvent casting technique in existence of polyethylene glycol 6000 as plasticizer. Physiochemical characterization studies including mechanical characteristics (tensile strength, elongation at break, and Young’s modulus), bioadhesion studies, in vitro and ex vivo drug release studies were conducted. Results: Tensile strength of drug loaded ophthalmic implants were 10.70 and 11.68 MPa respectively. Elongation at break of Carboxymethyl cellulose and Chitosan implants were 62.00% and 59.05% respectively. The in vitro release profiles fit into the Higuchi type kinetic model. Ex vivo release study results for both implants were correlated with in vitro release investigations. Conclusion: Carboxymethyl cellulose and Chitosan based implants provide extended drug delivery. Implants were prepared by using carboxymethyl cellulose provide significantly slower in vitro release rate, and the drug retention on ocular surfaces has been increased. Thus, it has been concluded that, dorzolamide loaded carboxymethyl cellulose implants could provide effective treatment for glaucomaen_US
dc.identifier.citationÖzdemir, S., Çakırlı, E., Bilge S., Aygüler, C. İ., Üner, B. & Çelebi, A. R. C. (2023). Preparation and characterization studies of dorzolamide loaded ophthalmic implants for the treatment of glaucoma. The Turkish Journal of Pharmaceutical Sciences, 20(3), pp. 149-156. https://doi.org/10.4274/tjps.galenos.2022.95752en_US
dc.identifier.doi10.4274/tjps.galenos.2022.95752en_US
dc.identifier.endpage156en_US
dc.identifier.issn1304-530X
dc.identifier.issue3en_US
dc.identifier.pmidPMID: 37417193en_US
dc.identifier.scopus2-s2.0-85163830768en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage149en_US
dc.identifier.urihttps://doi.org/10.4274/tjps.galenos.2022.95752
dc.identifier.urihttps://hdl.handle.net/20.500.13055/351
dc.identifier.volume20en_US
dc.identifier.wosWOS:001041092600003en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Indexen_US
dc.institutionauthorÖzdemir, Samet
dc.language.isoenen_US
dc.publisherTurkish Pharmacists Associationen_US
dc.relation.ispartofThe Turkish Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDorzolamideen_US
dc.subjectCarboxymethyl Celluloseen_US
dc.subjectChitosanen_US
dc.subjectOcular Implanten_US
dc.titlePreparation and characterization studies of dorzolamide loaded ophthalmic implants for the treatment of glaucomaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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