Ubiquitin proteasomal system is a potential target of the toxic effects of organophosphorus flame retardant triphenyl phosphate
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The consumption of the widely used flame retardant Triphenyl phosphate (TPP) is increasing. It is now frequently detected in the environment and also domestically. Although the possibility of dermal exposure to TPP is quite high, little is known about its potential molecular toxicity mechanisms. In this study, we found that TPP caused cytotoxicity on human skin keratinocytes (HaCaT) and significantly inhibited the proliferation and cell migration in a concentration-dependent manner. Additionally, HaCaT cells were sensitive to TPP-induced apoptosis. Reactive oxygen species production was induced with TPP, which increased the protein carbonyla- tion and lipid peroxidation levels. Moreover, TPP inhibited proteasome activity and increased the accumulation of ubiquitinated proteins. Exposure to TPP significantly increased the HSP90, HSP70, GRP94 and GRP78 protein levels. Overall, our findings indicate that TPP may pose a risk to human health and contribute to the current understanding of the risks of TPP at the molecular level.
Açıklama
İstanbul Üniversitesi -- TAB-2021-37247
Anahtar Kelimeler
Triphenyl Phosphate, Proteasome Activity, Oxidative Stress, Heat Shock Stress, Endoplasmic Reticulum Stress
Kaynak
Environmental Toxicology and Pharmacology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
96
Sayı
Künye
Jannuzzi, A. T., Yılmaz Göler, A. M. & Alpertunga, B. (2022). Ubiquitin proteasomal system is a potential target of the toxic effects of organophosphorus flame retardant triphenyl phosphate. Environmental Toxicology and Pharmacology, 96, pp. 1-10. https://doi.org/10.1016/j.etap.2022.104005
