Ubiquitin proteasomal system is a potential target of the toxic effects of organophosphorus flame retardant triphenyl phosphate

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dc.authorid0000-0001-6043-7560en_US
dc.authorscopusid6602718563en_US
dc.authorwosidAAD-6135-2020en_US
dc.contributor.authorJannuzzi, Ayse Tarbin
dc.contributor.authorYılmaz Göler, Ayşe Mine
dc.contributor.authorAlpertunga, Buket
dc.date.accessioned2022-11-15T11:06:46Z
dc.date.available2022-11-15T11:06:46Z
dc.date.issued2022en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Toksikoloji Ana Bilim Dalıen_US
dc.descriptionİstanbul Üniversitesi -- TAB-2021-37247en_US
dc.description.abstractThe consumption of the widely used flame retardant Triphenyl phosphate (TPP) is increasing. It is now frequently detected in the environment and also domestically. Although the possibility of dermal exposure to TPP is quite high, little is known about its potential molecular toxicity mechanisms. In this study, we found that TPP caused cytotoxicity on human skin keratinocytes (HaCaT) and significantly inhibited the proliferation and cell migration in a concentration-dependent manner. Additionally, HaCaT cells were sensitive to TPP-induced apoptosis. Reactive oxygen species production was induced with TPP, which increased the protein carbonyla- tion and lipid peroxidation levels. Moreover, TPP inhibited proteasome activity and increased the accumulation of ubiquitinated proteins. Exposure to TPP significantly increased the HSP90, HSP70, GRP94 and GRP78 protein levels. Overall, our findings indicate that TPP may pose a risk to human health and contribute to the current understanding of the risks of TPP at the molecular level.en_US
dc.identifier.citationJannuzzi, A. T., Yılmaz Göler, A. M. & Alpertunga, B. (2022). Ubiquitin proteasomal system is a potential target of the toxic effects of organophosphorus flame retardant triphenyl phosphate. Environmental Toxicology and Pharmacology, 96, pp. 1-10. https://doi.org/10.1016/j.etap.2022.104005en_US
dc.identifier.doi10.1016/j.etap.2022.104005en_US
dc.identifier.endpage10en_US
dc.identifier.issn1382-6689
dc.identifier.pmidPMID: 36367495en_US
dc.identifier.scopus2-s2.0-85141288968en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.etap.2022.104005
dc.identifier.urihttps://hdl.handle.net/20.500.13055/310
dc.identifier.volume96en_US
dc.identifier.wosWOS:000883791900004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorAlpertunga, Buket
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEnvironmental Toxicology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTriphenyl Phosphateen_US
dc.subjectProteasome Activityen_US
dc.subjectOxidative Stressen_US
dc.subjectHeat Shock Stressen_US
dc.subjectEndoplasmic Reticulum Stressen_US
dc.titleUbiquitin proteasomal system is a potential target of the toxic effects of organophosphorus flame retardant triphenyl phosphateen_US
dc.typeArticleen_US
dspace.entity.typePublication

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