Nesfatin-1 and neuronostatin neurons are co-expressed with glucocorticoid receptors in the hypothalamus
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor and Francis
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Nesfatin-1 and neuronostatin in the central nervous system participate in regulating stress responses. Glucocorticoid hormones affect the brain through glucocorticoid receptors (GR). We investigated in the rat the possibility of co-localizing nesfatin-1 and neuronostatin neurons in hypothalamic areas with GR. using immunohistochemistry. We counted nesfatin-1 and neuronostatin stained neurons. We counted GR positive nesfatin-1 neurons in the arcuate nucleus (ARC) and paraventricular nucleus (PVN) and GR positive neuronostatin neurons in the periventricular nucleus (PeN). The percentage of nesfatin-1 neurons that expressed GR was 38.4% in female rats and 21.9% in male rats in the ARC, and 33.3% in female rats and 29.2% in male rats in the PVN. The percentage of neuronostatin neurons that expressed GR was 39.1% in female rats and 39.9% in male rats in the PeN. We found that a substantial portion of nesfatin-1 and neuronostatin neurons were stained for GR. We speculate that the pattern of GR might permit secretion of neuropeptides to be stimulated by peripheral glucocorticoid signals. Stress can suppress food intake, in part, through the GR in neurons that express nesfatin-1, which is a satiety molecule, and in neurons that express neuronostatin, which is an anorexigenic peptide.
Açıklama
Anahtar Kelimeler
Glucocorticoid, Hypothalamus, Nesfatin-1, Neuronostatin, Rat, Receptors, Stress
Kaynak
Biotechnic and Histochemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
96
Sayı
7
Künye
Ekizceli, G., Halk, K. Z., Minbay, Z., & Eyigör, Ö. (2021). Nesfatin-1 and neuronostatin neurons are co-expressed with glucocorticoid receptors in the hypothalamus. Biotechnic and Histochemistry. 96(7). pp. 555-561. https://doi.org/10.1080/10520295.2020.1832703
