Nesfatin-1 and neuronostatin neurons are co-expressed with glucocorticoid receptors in the hypothalamus

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dc.authorid0000-0001-9513-5706en_US
dc.authorscopusid57195559466en_US
dc.authorwosidAAP-3523-2020en_US
dc.contributor.authorEkizceli, Gülçin
dc.contributor.authorHalk, Kıymet Zülal
dc.contributor.authorMinbay, Zehra
dc.contributor.authorEyigör, Özhan
dc.date.accessioned2021-12-23T07:28:15Z
dc.date.available2021-12-23T07:28:15Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractNesfatin-1 and neuronostatin in the central nervous system participate in regulating stress responses. Glucocorticoid hormones affect the brain through glucocorticoid receptors (GR). We investigated in the rat the possibility of co-localizing nesfatin-1 and neuronostatin neurons in hypothalamic areas with GR. using immunohistochemistry. We counted nesfatin-1 and neuronostatin stained neurons. We counted GR positive nesfatin-1 neurons in the arcuate nucleus (ARC) and paraventricular nucleus (PVN) and GR positive neuronostatin neurons in the periventricular nucleus (PeN). The percentage of nesfatin-1 neurons that expressed GR was 38.4% in female rats and 21.9% in male rats in the ARC, and 33.3% in female rats and 29.2% in male rats in the PVN. The percentage of neuronostatin neurons that expressed GR was 39.1% in female rats and 39.9% in male rats in the PeN. We found that a substantial portion of nesfatin-1 and neuronostatin neurons were stained for GR. We speculate that the pattern of GR might permit secretion of neuropeptides to be stimulated by peripheral glucocorticoid signals. Stress can suppress food intake, in part, through the GR in neurons that express nesfatin-1, which is a satiety molecule, and in neurons that express neuronostatin, which is an anorexigenic peptide.en_US
dc.identifier.citationEkizceli, G., Halk, K. Z., Minbay, Z., & Eyigör, Ö. (2021). Nesfatin-1 and neuronostatin neurons are co-expressed with glucocorticoid receptors in the hypothalamus. Biotechnic and Histochemistry. 96(7). pp. 555-561. https://doi.org/10.1080/10520295.2020.1832703en_US
dc.identifier.doi10.1080/10520295.2020.1832703en_US
dc.identifier.endpage561en_US
dc.identifier.issue7en_US
dc.identifier.pmidPMID: 33054452en_US
dc.identifier.scopus2-s2.0-85092576912en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage555en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2020.1832703
dc.identifier.urihttps://hdl.handle.net/20.500.13055/107
dc.identifier.volume96en_US
dc.identifier.wosWOS:000577345900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorEkizceli, Gülçin
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.hasversionWhen this article originally published, the first sentence in the section “Tissue processing and immunohistochemical double staining” read: Rats were anesthetized by injecting 70 mg/kg sodium pentobarbital intraperitoneally (i.p.). The sentence has now been correct as follows: Rats were deeply anesthetized with ether inhalation. -- WOS:000582911400001 -- https://doi.org/10.1080/10520295.2020.1841995
dc.relation.ispartofBiotechnic and Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlucocorticoiden_US
dc.subjectHypothalamusen_US
dc.subjectNesfatin-1en_US
dc.subjectNeuronostatinen_US
dc.subjectRaten_US
dc.subjectReceptorsen_US
dc.subjectStressen_US
dc.titleNesfatin-1 and neuronostatin neurons are co-expressed with glucocorticoid receptors in the hypothalamusen_US
dc.typeArticleen_US
dspace.entity.typePublication

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